Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline
A 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that the addition of amitriptyline to carbamazepin...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/183252 |
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| _version_ | 1832567430037110784 |
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| author | A. Bruce Janati Naif ALGhasab Aboubaker Osman |
| author_facet | A. Bruce Janati Naif ALGhasab Aboubaker Osman |
| author_sort | A. Bruce Janati |
| collection | DOAJ |
| description | A 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that the addition of amitriptyline to carbamazepine caused a decrease in the serum level of carbamazepine, resulting in NMS. We conclude that combination therapy with carbamazepine and amitriptyline should be avoided in patients who are predisposed to NMS. The purpose of this paper is to warn physicians against combination therapy with carbamazepine and tricyclic antidepressants which may be conducive to neuroleptic malignant syndrome in susceptible patients. |
| format | Article |
| id | doaj-art-20c7c4a557404f39bda297307ec1f6e8 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-20c7c4a557404f39bda297307ec1f6e82025-02-03T01:01:33ZengWileyCase Reports in Neurological Medicine2090-66682090-66762012-01-01201210.1155/2012/183252183252Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and AmitriptylineA. Bruce Janati0Naif ALGhasab1Aboubaker Osman2Center For Neurology, Fairfax, VA 22031, USADepartment of Neuroscience, King Khaled Hospital, 81442 Hail, Saudi ArabiaDepartment of Neuroscience, King Khaled Hospital, 81442 Hail, Saudi ArabiaA 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that the addition of amitriptyline to carbamazepine caused a decrease in the serum level of carbamazepine, resulting in NMS. We conclude that combination therapy with carbamazepine and amitriptyline should be avoided in patients who are predisposed to NMS. The purpose of this paper is to warn physicians against combination therapy with carbamazepine and tricyclic antidepressants which may be conducive to neuroleptic malignant syndrome in susceptible patients.http://dx.doi.org/10.1155/2012/183252 |
| spellingShingle | A. Bruce Janati Naif ALGhasab Aboubaker Osman Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline Case Reports in Neurological Medicine |
| title | Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline |
| title_full | Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline |
| title_fullStr | Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline |
| title_full_unstemmed | Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline |
| title_short | Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline |
| title_sort | neuroleptic malignant syndrome caused by a combination of carbamazepine and amitriptyline |
| url | http://dx.doi.org/10.1155/2012/183252 |
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