Identification and validation of mitochondria-related genes in panvascular diseases
Panvascular diseases represent a spectrum of vascular conditions where atherosclerosis plays a central role in the pathophysiology. This study focused on identifying differentially expressed genes (DEGs) related to mitochondria and key genes associated with peripheral artery disease (PAD) and corona...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1614342/full |
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| author | Yingfen Li Yingfen Li Shenzhou Ma Guang Yang |
| author_facet | Yingfen Li Yingfen Li Shenzhou Ma Guang Yang |
| author_sort | Yingfen Li |
| collection | DOAJ |
| description | Panvascular diseases represent a spectrum of vascular conditions where atherosclerosis plays a central role in the pathophysiology. This study focused on identifying differentially expressed genes (DEGs) related to mitochondria and key genes associated with peripheral artery disease (PAD) and coronary artery disease (CAD). This study identified MPV17 as a key mitochondrial gene bridging peripheral artery disease (PAD) and coronary artery disease (CAD). Analysis of GEO datasets revealed differentially expressed mitochondrial genes, with MPV17, FADD, HLCS, and PEX3 highlighted. A diagnostic nomogram, developed using LASSO and Random Forest methods, demonstrated high accuracy in predicting PAD and CAD (AUC >0.93). Furthermore, the study revealed significant alterations in immune cell infiltration associated with both diseases, suggesting a potential role for immune modulation in panvascular disease. MPV17 shows promise as a diagnostic marker for early identification and differentiation of these vascular conditions. |
| format | Article |
| id | doaj-art-20c1a6f20af644d8b1d40fdf0f4e4d2e |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-20c1a6f20af644d8b1d40fdf0f4e4d2e2025-08-20T03:28:48ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16143421614342Identification and validation of mitochondria-related genes in panvascular diseasesYingfen Li0Yingfen Li1Shenzhou Ma2Guang Yang3Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Gerontology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Gerontology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaPanvascular diseases represent a spectrum of vascular conditions where atherosclerosis plays a central role in the pathophysiology. This study focused on identifying differentially expressed genes (DEGs) related to mitochondria and key genes associated with peripheral artery disease (PAD) and coronary artery disease (CAD). This study identified MPV17 as a key mitochondrial gene bridging peripheral artery disease (PAD) and coronary artery disease (CAD). Analysis of GEO datasets revealed differentially expressed mitochondrial genes, with MPV17, FADD, HLCS, and PEX3 highlighted. A diagnostic nomogram, developed using LASSO and Random Forest methods, demonstrated high accuracy in predicting PAD and CAD (AUC >0.93). Furthermore, the study revealed significant alterations in immune cell infiltration associated with both diseases, suggesting a potential role for immune modulation in panvascular disease. MPV17 shows promise as a diagnostic marker for early identification and differentiation of these vascular conditions.https://www.frontiersin.org/articles/10.3389/fmed.2025.1614342/fullpanvascular diseasesperipheral artery diseasecoronary artery diseasemitochondria-related genesimmune infiltration |
| spellingShingle | Yingfen Li Yingfen Li Shenzhou Ma Guang Yang Identification and validation of mitochondria-related genes in panvascular diseases Frontiers in Medicine panvascular diseases peripheral artery disease coronary artery disease mitochondria-related genes immune infiltration |
| title | Identification and validation of mitochondria-related genes in panvascular diseases |
| title_full | Identification and validation of mitochondria-related genes in panvascular diseases |
| title_fullStr | Identification and validation of mitochondria-related genes in panvascular diseases |
| title_full_unstemmed | Identification and validation of mitochondria-related genes in panvascular diseases |
| title_short | Identification and validation of mitochondria-related genes in panvascular diseases |
| title_sort | identification and validation of mitochondria related genes in panvascular diseases |
| topic | panvascular diseases peripheral artery disease coronary artery disease mitochondria-related genes immune infiltration |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1614342/full |
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