Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor
Objective. To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. Methods. Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis p...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/732902 |
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| author | Ya-Juan Zhao Qiang Li Bai-Xiang Cheng Min Zhang Yong-Jin Chen |
| author_facet | Ya-Juan Zhao Qiang Li Bai-Xiang Cheng Min Zhang Yong-Jin Chen |
| author_sort | Ya-Juan Zhao |
| collection | DOAJ |
| description | Objective. To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. Methods. Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group. Then, the rats were sacrificed at baseline and week(s) 1, 2, and 4. The periodontitis healing condition was assessed, and the expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and bFGF were tested by immunohistochemistry. Results. The stressed rats showed reduced body weight gain, behavioral changes, and increased serum corticosterone and ACTH levels (). The surface of inflammatory infiltrate, alveolar bone loss, attachment loss, and expression of IL-1β and TNF-α in the stress group were higher than those in the periodontitis group at weeks 2 and 4 (). Rats with experimental periodontitis showed decreased bFGF expression (), and the recovery of bFGF expression in the stress group was slower than that in the periodontitis group (). Negative correlations between inflammatory cytokines and bFGF were detected. Conclusion. Psychological stress could delay periodontitis healing in rats, which may be partly mediated by downregulation of the expression of bFGF in the periodontal ligament. |
| format | Article |
| id | doaj-art-20c1960ea2c04d07a503af0b90140f38 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-20c1960ea2c04d07a503af0b90140f382025-02-03T05:58:42ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/732902732902Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth FactorYa-Juan Zhao0Qiang Li1Bai-Xiang Cheng2Min Zhang3Yong-Jin Chen4Department of General Dentistry and Emergency, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi 710032, ChinaDepartment of General Dentistry and Emergency, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi 710032, ChinaDepartment of General Dentistry and Emergency, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi 710032, ChinaDepartment of General Dentistry and Emergency, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi 710032, ChinaDepartment of General Dentistry and Emergency, School of Stomatology, Fourth Military Medical University, No. 145 Changle West Road, Xi'an, Shaanxi 710032, ChinaObjective. To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. Methods. Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group. Then, the rats were sacrificed at baseline and week(s) 1, 2, and 4. The periodontitis healing condition was assessed, and the expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and bFGF were tested by immunohistochemistry. Results. The stressed rats showed reduced body weight gain, behavioral changes, and increased serum corticosterone and ACTH levels (). The surface of inflammatory infiltrate, alveolar bone loss, attachment loss, and expression of IL-1β and TNF-α in the stress group were higher than those in the periodontitis group at weeks 2 and 4 (). Rats with experimental periodontitis showed decreased bFGF expression (), and the recovery of bFGF expression in the stress group was slower than that in the periodontitis group (). Negative correlations between inflammatory cytokines and bFGF were detected. Conclusion. Psychological stress could delay periodontitis healing in rats, which may be partly mediated by downregulation of the expression of bFGF in the periodontal ligament.http://dx.doi.org/10.1155/2012/732902 |
| spellingShingle | Ya-Juan Zhao Qiang Li Bai-Xiang Cheng Min Zhang Yong-Jin Chen Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor Mediators of Inflammation |
| title | Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor |
| title_full | Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor |
| title_fullStr | Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor |
| title_full_unstemmed | Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor |
| title_short | Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor |
| title_sort | psychological stress delays periodontitis healing in rats the involvement of basic fibroblast growth factor |
| url | http://dx.doi.org/10.1155/2012/732902 |
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