SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases
Toll-like receptor (TLR) signaling pathways are strictly coordinated by several mechanisms to regulate adequate innate immune responses. Recent lines of evidence indicate that the suppressor of cytokine signaling (SOCS) family proteins, originally identified as negative-feedback regulators in cytoki...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/470468 |
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| author | Minoru Fujimoto Tetsuji Naka |
| author_facet | Minoru Fujimoto Tetsuji Naka |
| author_sort | Minoru Fujimoto |
| collection | DOAJ |
| description | Toll-like receptor (TLR) signaling pathways are strictly coordinated by several mechanisms to regulate adequate innate immune responses. Recent lines of evidence indicate that the suppressor of cytokine signaling (SOCS) family proteins, originally identified as negative-feedback regulators in cytokine signaling, are involved in the regulation of TLR-mediated immune responses. SOCS1, a member of SOCS family, is strongly induced upon TLR stimulation. Cells lacking SOCS1 are hyperresponsive to TLR stimulation. Thus, SOCS1 is an important regulator for both cytokine and TLR-induced responses. As an immune organ, the liver contains various types of immune cells such as T cells, NK cells, NKT cells, and Kupffer cells and is continuously challenged with gut-derived bacterial and dietary antigens. SOCS1 may be implicated in pathophysiology of the liver. The studies using SOCS1-deficient mice revealed that endogenous SOCS1 is critical for the prevention of liver diseases such as hepatitis, cirrhosis, and cancers. Recent studies on humans suggest that SOCS1 is involved in the development of various liver disorders in humans. Thus, SOCS1 and other SOCS proteins are potential targets for the therapy of human liver diseases. |
| format | Article |
| id | doaj-art-20bb811a75b6427b96e270d47502d44d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-20bb811a75b6427b96e270d47502d44d2025-02-03T05:43:58ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/470468470468SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver DiseasesMinoru Fujimoto0Tetsuji Naka1Laboratory for Immune Signal, National Institute of Biomedical Innovation, 7-6-8 Saitoasagi, Ibaraki, Osaka 567-0085, JapanLaboratory for Immune Signal, National Institute of Biomedical Innovation, 7-6-8 Saitoasagi, Ibaraki, Osaka 567-0085, JapanToll-like receptor (TLR) signaling pathways are strictly coordinated by several mechanisms to regulate adequate innate immune responses. Recent lines of evidence indicate that the suppressor of cytokine signaling (SOCS) family proteins, originally identified as negative-feedback regulators in cytokine signaling, are involved in the regulation of TLR-mediated immune responses. SOCS1, a member of SOCS family, is strongly induced upon TLR stimulation. Cells lacking SOCS1 are hyperresponsive to TLR stimulation. Thus, SOCS1 is an important regulator for both cytokine and TLR-induced responses. As an immune organ, the liver contains various types of immune cells such as T cells, NK cells, NKT cells, and Kupffer cells and is continuously challenged with gut-derived bacterial and dietary antigens. SOCS1 may be implicated in pathophysiology of the liver. The studies using SOCS1-deficient mice revealed that endogenous SOCS1 is critical for the prevention of liver diseases such as hepatitis, cirrhosis, and cancers. Recent studies on humans suggest that SOCS1 is involved in the development of various liver disorders in humans. Thus, SOCS1 and other SOCS proteins are potential targets for the therapy of human liver diseases.http://dx.doi.org/10.1155/2010/470468 |
| spellingShingle | Minoru Fujimoto Tetsuji Naka SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases Gastroenterology Research and Practice |
| title | SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses,
in Human Liver Diseases |
| title_full | SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses,
in Human Liver Diseases |
| title_fullStr | SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses,
in Human Liver Diseases |
| title_full_unstemmed | SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses,
in Human Liver Diseases |
| title_short | SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses,
in Human Liver Diseases |
| title_sort | socs1 a negative regulator of cytokine signals and tlr responses in human liver diseases |
| url | http://dx.doi.org/10.1155/2010/470468 |
| work_keys_str_mv | AT minorufujimoto socs1anegativeregulatorofcytokinesignalsandtlrresponsesinhumanliverdiseases AT tetsujinaka socs1anegativeregulatorofcytokinesignalsandtlrresponsesinhumanliverdiseases |