The Roles of UmuD in Regulating Mutagenesis
All organisms are subject to DNA damage from both endogenous and environmental sources. DNA damage that is not fully repaired can lead to mutations. Mutagenesis is now understood to be an active process, i...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/947680 |
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| Summary: | All organisms are
subject to DNA damage from both endogenous and
environmental sources. DNA damage that is not
fully repaired can lead to mutations.
Mutagenesis is now understood to be an active
process, in part facilitated by lower-fidelity
DNA polymerases that replicate DNA in an
error-prone manner. Y-family DNA polymerases,
found throughout all domains of life, are
characterized by their lower fidelity on
undamaged DNA and their specialized ability to
copy damaged DNA. Two E. coli Y-family DNA polymerases are responsible for
copying damaged DNA as well as for mutagenesis.
These DNA polymerases interact with different
forms of UmuD, a dynamic protein that regulates
mutagenesis. The UmuD gene
products, regulated by the SOS response, exist
in two principal forms: UmuD2, which prevents mutagenesis, and UmuD2′, which facilitates UV-induced mutagenesis. This paper focuses on the multiple conformations of the UmuD gene products and how their protein interactions regulate mutagenesis. |
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| ISSN: | 2090-021X |