Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity
In Parkinson’s disease (PD) and other synucleinopathies, chronic neurodegeneration occurs within different areas of the central nervous system leading to progressive motor and nonmotor symptoms. The symptomatic treatment options that are currently available do not slow or halt disease progression. T...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/454696 |
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| author | Martin Regensburger Iryna Prots Beate Winner |
| author_facet | Martin Regensburger Iryna Prots Beate Winner |
| author_sort | Martin Regensburger |
| collection | DOAJ |
| description | In Parkinson’s disease (PD) and other synucleinopathies, chronic neurodegeneration occurs within different areas of the central nervous system leading to progressive motor and nonmotor symptoms. The symptomatic treatment options that are currently available do not slow or halt disease progression. This highlights the need of a better understanding of disease mechanisms and disease models. The generation of newborn neurons in the adult hippocampus and in the subventricular zone/olfactory bulb system is affected by many different regulators and possibly involved in memory processing, depression, and olfaction, symptoms which commonly occur in PD. The pathology of the adult neurogenic niches in human PD patients is still mostly elusive, but different preclinical models have shown profound alterations of adult neurogenesis. Alterations in stem cell proliferation, differentiation, and survival as well as neurite outgrowth and spine formation have been related to different aspects in PD pathogenesis. Therefore, neurogenesis in the adult brain provides an ideal model to study disease mechanisms and compounds. In addition, adult newborn neurons have been proposed as a source of endogenous repair. Herein, we review current knowledge about the adult neurogenic niches in PD and highlight areas of future research. |
| format | Article |
| id | doaj-art-20a97abfc6c444ba903b5dec43c15e15 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-20a97abfc6c444ba903b5dec43c15e152025-02-03T01:01:12ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/454696454696Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and PlasticityMartin Regensburger0Iryna Prots1Beate Winner2IZKF Junior Research Group and BMBF Research Group Neuroscience, IZKF, Friedrich-Alexander University of Erlangen-Nuernberg (FAU), Glückstraße 6, 91054 Erlangen, GermanyIZKF Junior Research Group and BMBF Research Group Neuroscience, IZKF, Friedrich-Alexander University of Erlangen-Nuernberg (FAU), Glückstraße 6, 91054 Erlangen, GermanyIZKF Junior Research Group and BMBF Research Group Neuroscience, IZKF, Friedrich-Alexander University of Erlangen-Nuernberg (FAU), Glückstraße 6, 91054 Erlangen, GermanyIn Parkinson’s disease (PD) and other synucleinopathies, chronic neurodegeneration occurs within different areas of the central nervous system leading to progressive motor and nonmotor symptoms. The symptomatic treatment options that are currently available do not slow or halt disease progression. This highlights the need of a better understanding of disease mechanisms and disease models. The generation of newborn neurons in the adult hippocampus and in the subventricular zone/olfactory bulb system is affected by many different regulators and possibly involved in memory processing, depression, and olfaction, symptoms which commonly occur in PD. The pathology of the adult neurogenic niches in human PD patients is still mostly elusive, but different preclinical models have shown profound alterations of adult neurogenesis. Alterations in stem cell proliferation, differentiation, and survival as well as neurite outgrowth and spine formation have been related to different aspects in PD pathogenesis. Therefore, neurogenesis in the adult brain provides an ideal model to study disease mechanisms and compounds. In addition, adult newborn neurons have been proposed as a source of endogenous repair. Herein, we review current knowledge about the adult neurogenic niches in PD and highlight areas of future research.http://dx.doi.org/10.1155/2014/454696 |
| spellingShingle | Martin Regensburger Iryna Prots Beate Winner Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity Neural Plasticity |
| title | Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity |
| title_full | Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity |
| title_fullStr | Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity |
| title_full_unstemmed | Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity |
| title_short | Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity |
| title_sort | adult hippocampal neurogenesis in parkinson s disease impact on neuronal survival and plasticity |
| url | http://dx.doi.org/10.1155/2014/454696 |
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