Paclitaxel triggers molecular and cellular changes in the choroid plexus

Paclitaxel triggers molecular and cellular changes in the choroid plexus

Paclitaxel is a widely used chemotherapeutic agent for treating various solid tumors. However, resulting neuropathic pain, often a lifelong side effect of paclitaxel, can limit dosing and compromise optimal treatment. The choroid plexus, located in the brain ventricles, spreads peripheral inflammato...

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Bibliographic Details
Main Authors: Alemeh Zamani, Parisa EmamiAref, Lucie Kubíčková, Klaudia Hašanová, Ondřej Šandor, Petr Dubový, Marek Joukal
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pain Research
Subjects:
choroid plexus
paclitaxel
blood-CSF barrier
DAMPs
neuroinflammation
PINP
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2024.1488369/full
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