Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension
Aim. We investigated the relationship between brachial-ankle pulse wave velocity (baPWV) and glucose levels, insulin sensitivity, and beta-cell function in Chinese individuals with or without hypertension. Methods. We recruited 3137 nondiabetic individuals whose age, body mass index (BMI), glucose l...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/151675 |
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| author | Chuchen Meng Min Sun Zhixiao Wang Qi Fu Mengdie Cao Zhenxin Zhu Jia Mao Yun Shi Wei Tang Xiaoping Huang Yu Duan Tao Yang |
| author_facet | Chuchen Meng Min Sun Zhixiao Wang Qi Fu Mengdie Cao Zhenxin Zhu Jia Mao Yun Shi Wei Tang Xiaoping Huang Yu Duan Tao Yang |
| author_sort | Chuchen Meng |
| collection | DOAJ |
| description | Aim. We investigated the relationship between brachial-ankle pulse wave velocity (baPWV)
and glucose levels, insulin sensitivity, and beta-cell function in Chinese individuals with or
without hypertension. Methods. We recruited 3137 nondiabetic individuals whose age, body mass index (BMI),
glucose levels, blood pressure (BP), lipids, hemoglobin A1C (HbA1c), baPWV, and insulin levels
were measured. Results. In normotensive group, 2 h glucose levels (β=0.046, P<0.001) associated with baPWV, showed a significant increase in patients with NG as compared to those with DM (P=0.032). The hypertensive group showed no such differences. The Matsuda index (β=0.114, P<0.001) and HOMA-β (β=0.045, P<0.001) were negatively correlated with baPWV while lnHOMA-IR (β=0.196, P=0.076) and the Quantitative Insulin Sensitivity Check Index (QUICKI) (β=0.226, P=0.046) showed a borderline negative correlation. BaPWV significantly decreased (P=0.032) with an increase in insulin sensitivity in individuals with both normal BP and glucose tolerance. Conclusions. BaPWV was significantly associated with 2 h glucose levels, insulin sensitivity and
beta-cell function in normotensive population, whereas in hypertensive individuals, BP was the
dominant factor influencing arterial stiffness. Individuals with abnormal insulin sensitivity in the
absence of diabetes and hypertension are also at an increased risk of arterial stiffness. |
| format | Article |
| id | doaj-art-209ea297f07f430d9959118de2580832 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-209ea297f07f430d9959118de25808322025-02-03T05:48:16ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/151675151675Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without HypertensionChuchen Meng0Min Sun1Zhixiao Wang2Qi Fu3Mengdie Cao4Zhenxin Zhu5Jia Mao6Yun Shi7Wei Tang8Xiaoping Huang9Yu Duan10Tao Yang11Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, ChinaAim. We investigated the relationship between brachial-ankle pulse wave velocity (baPWV) and glucose levels, insulin sensitivity, and beta-cell function in Chinese individuals with or without hypertension. Methods. We recruited 3137 nondiabetic individuals whose age, body mass index (BMI), glucose levels, blood pressure (BP), lipids, hemoglobin A1C (HbA1c), baPWV, and insulin levels were measured. Results. In normotensive group, 2 h glucose levels (β=0.046, P<0.001) associated with baPWV, showed a significant increase in patients with NG as compared to those with DM (P=0.032). The hypertensive group showed no such differences. The Matsuda index (β=0.114, P<0.001) and HOMA-β (β=0.045, P<0.001) were negatively correlated with baPWV while lnHOMA-IR (β=0.196, P=0.076) and the Quantitative Insulin Sensitivity Check Index (QUICKI) (β=0.226, P=0.046) showed a borderline negative correlation. BaPWV significantly decreased (P=0.032) with an increase in insulin sensitivity in individuals with both normal BP and glucose tolerance. Conclusions. BaPWV was significantly associated with 2 h glucose levels, insulin sensitivity and beta-cell function in normotensive population, whereas in hypertensive individuals, BP was the dominant factor influencing arterial stiffness. Individuals with abnormal insulin sensitivity in the absence of diabetes and hypertension are also at an increased risk of arterial stiffness.http://dx.doi.org/10.1155/2013/151675 |
| spellingShingle | Chuchen Meng Min Sun Zhixiao Wang Qi Fu Mengdie Cao Zhenxin Zhu Jia Mao Yun Shi Wei Tang Xiaoping Huang Yu Duan Tao Yang Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension Journal of Diabetes Research |
| title | Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension |
| title_full | Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension |
| title_fullStr | Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension |
| title_full_unstemmed | Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension |
| title_short | Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension |
| title_sort | insulin sensitivity and beta cell function are associated with arterial stiffness in individuals without hypertension |
| url | http://dx.doi.org/10.1155/2013/151675 |
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