The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex
Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert the...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/6871089 |
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| _version_ | 1832550679877517312 |
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| author | Wei Liu Tongtong Ge Yashu Leng Zhenxiang Pan Jie Fan Wei Yang Ranji Cui |
| author_facet | Wei Liu Tongtong Ge Yashu Leng Zhenxiang Pan Jie Fan Wei Yang Ranji Cui |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. However, the detailed mechanisms of neural plasticity in depression still remain unclear. Therefore, in this review, we summarize the recent literature to elaborate the possible mechanistic role of neural plasticity in depression. Taken together, these findings may pave the way for future progress in neural plasticity studies. |
| format | Article |
| id | doaj-art-209ba6932bc04454be884e06c1d0eadc |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-209ba6932bc04454be884e06c1d0eadc2025-02-03T06:06:09ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/68710896871089The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal CortexWei Liu0Tongtong Ge1Yashu Leng2Zhenxiang Pan3Jie Fan4Wei Yang5Ranji Cui6Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaAnesthesiology Department, The Third Hospital of Jilin University, 126 Xiantai Street, Changchun 130033, ChinaAnesthesiology Department, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaNeural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. However, the detailed mechanisms of neural plasticity in depression still remain unclear. Therefore, in this review, we summarize the recent literature to elaborate the possible mechanistic role of neural plasticity in depression. Taken together, these findings may pave the way for future progress in neural plasticity studies.http://dx.doi.org/10.1155/2017/6871089 |
| spellingShingle | Wei Liu Tongtong Ge Yashu Leng Zhenxiang Pan Jie Fan Wei Yang Ranji Cui The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex Neural Plasticity |
| title | The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex |
| title_full | The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex |
| title_fullStr | The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex |
| title_full_unstemmed | The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex |
| title_short | The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex |
| title_sort | role of neural plasticity in depression from hippocampus to prefrontal cortex |
| url | http://dx.doi.org/10.1155/2017/6871089 |
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