The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment
Abstract Vitiligo is a dermatological condition that affects millions of individuals globally and is frequently precipitated by damage to or dysfunction of melanocytes. Despite the availability of various therapeutic options, the management of vitiligo remains a significant challenge, underscoring t...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06627-8 |
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| author | Rui-Lin Yang De-Zhi Zhao Yi-Bing Yang Han-Xiao Wei Kang Yang Yu-Jie Zhao Wei-Hong Wan Zu-Lin Liu Yuan Feng Qian Zhang Tao Zhang |
| author_facet | Rui-Lin Yang De-Zhi Zhao Yi-Bing Yang Han-Xiao Wei Kang Yang Yu-Jie Zhao Wei-Hong Wan Zu-Lin Liu Yuan Feng Qian Zhang Tao Zhang |
| author_sort | Rui-Lin Yang |
| collection | DOAJ |
| description | Abstract Vitiligo is a dermatological condition that affects millions of individuals globally and is frequently precipitated by damage to or dysfunction of melanocytes. Despite the availability of various therapeutic options, the management of vitiligo remains a significant challenge, underscoring the necessity for innovative treatment approaches. Currently, Mesenchymal Stromal Cells (MSCs) have gained prominence as a therapeutic modality in the research of numerous diseases, owing to their remarkable paracrine effects, making them a promising strategy for immunomodulation and tissue repair. The downregulation of specific cytokines by MSCs has the potential to enhance the microenvironment of vitiligo lesions, thereby contributing to therapeutic outcomes. This article aims to review the immunologic pathogenesis of vitiligo, the involvement of certain cytokines in its pathogenesis, and the therapeutic potential of MSCs in the treatment of vitiligo. It is anticipated that this review will serve as a reference for future therapeutic strategies involving MSCs in the management of vitiligo. |
| format | Article |
| id | doaj-art-2099d9f2671e418cb4c6a70fdf9cdd3d |
| institution | DOAJ |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-2099d9f2671e418cb4c6a70fdf9cdd3d2025-08-20T03:04:11ZengBMCJournal of Translational Medicine1479-58762025-07-0123111710.1186/s12967-025-06627-8The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatmentRui-Lin Yang0De-Zhi Zhao1Yi-Bing Yang2Han-Xiao Wei3Kang Yang4Yu-Jie Zhao5Wei-Hong Wan6Zu-Lin Liu7Yuan Feng8Qian Zhang9Tao Zhang10Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical UniversityKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical UniversityDepartment of Dermatology, Affiliated Hospital of Zunyi Medical UniversityKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical UniversityDepartment of Dermatology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Laboratory Medicine, Affiliated Hospital of Zunyi Medical UniversityKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical UniversityKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical UniversityKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical UniversityDepartment of Human Anatomy, Zunyi Medical UniversityKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical UniversityAbstract Vitiligo is a dermatological condition that affects millions of individuals globally and is frequently precipitated by damage to or dysfunction of melanocytes. Despite the availability of various therapeutic options, the management of vitiligo remains a significant challenge, underscoring the necessity for innovative treatment approaches. Currently, Mesenchymal Stromal Cells (MSCs) have gained prominence as a therapeutic modality in the research of numerous diseases, owing to their remarkable paracrine effects, making them a promising strategy for immunomodulation and tissue repair. The downregulation of specific cytokines by MSCs has the potential to enhance the microenvironment of vitiligo lesions, thereby contributing to therapeutic outcomes. This article aims to review the immunologic pathogenesis of vitiligo, the involvement of certain cytokines in its pathogenesis, and the therapeutic potential of MSCs in the treatment of vitiligo. It is anticipated that this review will serve as a reference for future therapeutic strategies involving MSCs in the management of vitiligo.https://doi.org/10.1186/s12967-025-06627-8VitiligoCytokinesMelanocytesKeratinocytesMesenchymal stromal/stem cells |
| spellingShingle | Rui-Lin Yang De-Zhi Zhao Yi-Bing Yang Han-Xiao Wei Kang Yang Yu-Jie Zhao Wei-Hong Wan Zu-Lin Liu Yuan Feng Qian Zhang Tao Zhang The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment Journal of Translational Medicine Vitiligo Cytokines Melanocytes Keratinocytes Mesenchymal stromal/stem cells |
| title | The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment |
| title_full | The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment |
| title_fullStr | The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment |
| title_full_unstemmed | The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment |
| title_short | The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment |
| title_sort | immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal stem cells in its treatment |
| topic | Vitiligo Cytokines Melanocytes Keratinocytes Mesenchymal stromal/stem cells |
| url | https://doi.org/10.1186/s12967-025-06627-8 |
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