Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation
The role of natural idiotypic (Id-Abs) and anti-idiotypic (AId-Abs) autoantibodies against neuro-antigens observed in different neurological disorders is not fully understood. In particular, limited experimental evidence has been provided concerning the qualitativ...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/10446670410001722221 |
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| author | A. B. Poletaev A. A. Abrosimova M. A. Sokolov A. B. Gekht V. V. Alferova E. I. Gusev T. Ya. Nikolaeva C. Selmi |
| author_facet | A. B. Poletaev A. A. Abrosimova M. A. Sokolov A. B. Gekht V. V. Alferova E. I. Gusev T. Ya. Nikolaeva C. Selmi |
| author_sort | A. B. Poletaev |
| collection | DOAJ |
| description | The role of natural idiotypic (Id-Abs) and anti-idiotypic (AId-Abs) autoantibodies
against neuro-antigens observed in different neurological disorders is not fully
understood. In particular, limited experimental evidence has been provided
concerning the qualitative and quantitative serological response after acute injuries
of the central nervous system or during chronic mental diseases. In this study, we
analyzed the specific Id-Abs and AId-Abs serological reactivities against 4
neuro-antigens in a large population of patients with ischemic stroke, schizophrenia,
as well as healthy individuals. Patients with ischemic stroke were tested at different
time points following the acute stroke episode and a correlation was attempted
between autoantibodies response and different patterns of functional recovery.
Results showed variable and detectable Id-Abs and AId-Abs in different proportions
of all three populations of subjects. Among patients with different functional
recovery after ischemic stroke, a difference in time-related trends of Id-Abs and
AId-Abs was encountered. Our observations suggest that changes in
the production of natural neurotropic Abs may engender a positive homeostatic,
beside a possible
pathogenic effect, in specific neurological disorders. |
| format | Article |
| id | doaj-art-20973bbc58e343f5ae23d13d63a6641e |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-20973bbc58e343f5ae23d13d63a6641e2025-02-03T05:59:55ZengWileyClinical and Developmental Immunology1740-25221740-25302004-01-0111215115610.1080/10446670410001722221Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and RehabilitationA. B. Poletaev0A. A. Abrosimova1M. A. Sokolov2A. B. Gekht3V. V. Alferova4E. I. Gusev5T. Ya. Nikolaeva6C. Selmi7Medical Research Center “Immunculus”, Moscow, RussiaMedical Research Center “Immunculus”, Moscow, RussiaMedical Research Center “Immunculus”, Moscow, RussiaDepartment of Neurology, Russian State Medical University, Moscow, RussiaDepartment of Neurology, Russian State Medical University, Moscow, RussiaDepartment of Neurology, Russian State Medical University, Moscow, RussiaYakutian State Research Center, Yakutsk, RussiaDivision of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USAThe role of natural idiotypic (Id-Abs) and anti-idiotypic (AId-Abs) autoantibodies against neuro-antigens observed in different neurological disorders is not fully understood. In particular, limited experimental evidence has been provided concerning the qualitative and quantitative serological response after acute injuries of the central nervous system or during chronic mental diseases. In this study, we analyzed the specific Id-Abs and AId-Abs serological reactivities against 4 neuro-antigens in a large population of patients with ischemic stroke, schizophrenia, as well as healthy individuals. Patients with ischemic stroke were tested at different time points following the acute stroke episode and a correlation was attempted between autoantibodies response and different patterns of functional recovery. Results showed variable and detectable Id-Abs and AId-Abs in different proportions of all three populations of subjects. Among patients with different functional recovery after ischemic stroke, a difference in time-related trends of Id-Abs and AId-Abs was encountered. Our observations suggest that changes in the production of natural neurotropic Abs may engender a positive homeostatic, beside a possible pathogenic effect, in specific neurological disorders.http://dx.doi.org/10.1080/10446670410001722221 |
| spellingShingle | A. B. Poletaev A. A. Abrosimova M. A. Sokolov A. B. Gekht V. V. Alferova E. I. Gusev T. Ya. Nikolaeva C. Selmi Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation Clinical and Developmental Immunology |
| title | Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation |
| title_full | Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation |
| title_fullStr | Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation |
| title_full_unstemmed | Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation |
| title_short | Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation |
| title_sort | dialectics and implications of natural neurotropic autoantibodies in neurological disease and rehabilitation |
| url | http://dx.doi.org/10.1080/10446670410001722221 |
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