Dialectics and Implications of Natural Neurotropic Autoantibodies in Neurological Disease and Rehabilitation
The role of natural idiotypic (Id-Abs) and anti-idiotypic (AId-Abs) autoantibodies against neuro-antigens observed in different neurological disorders is not fully understood. In particular, limited experimental evidence has been provided concerning the qualitativ...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2004-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/10446670410001722221 |
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| Summary: | The role of natural idiotypic (Id-Abs) and anti-idiotypic (AId-Abs) autoantibodies
against neuro-antigens observed in different neurological disorders is not fully
understood. In particular, limited experimental evidence has been provided
concerning the qualitative and quantitative serological response after acute injuries
of the central nervous system or during chronic mental diseases. In this study, we
analyzed the specific Id-Abs and AId-Abs serological reactivities against 4
neuro-antigens in a large population of patients with ischemic stroke, schizophrenia,
as well as healthy individuals. Patients with ischemic stroke were tested at different
time points following the acute stroke episode and a correlation was attempted
between autoantibodies response and different patterns of functional recovery.
Results showed variable and detectable Id-Abs and AId-Abs in different proportions
of all three populations of subjects. Among patients with different functional
recovery after ischemic stroke, a difference in time-related trends of Id-Abs and
AId-Abs was encountered. Our observations suggest that changes in
the production of natural neurotropic Abs may engender a positive homeostatic,
beside a possible
pathogenic effect, in specific neurological disorders. |
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| ISSN: | 1740-2522 1740-2530 |