Clinical Profile And Liver Functions In Dengue Fever
Objective: This cross-sectional study explores the complex effects of dengue fever on liver functions in individuals admitted to a Federal Government Polyclinic Hospital (PGMI), in Islamabad Methods: This prospective cross-sectional study evaluated 60 children aged 1–12 years with confirmed dengu...
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| Language: | English |
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Rawalpindi Medical University
2024-12-01
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| Series: | Journal of Rawalpindi Medical College |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2486 |
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| author | Saeeda Sadiq Amna Mobeen Naveed Ashraf Fasih Hashmi Shahzad Munir Anam Ahmad |
| author_facet | Saeeda Sadiq Amna Mobeen Naveed Ashraf Fasih Hashmi Shahzad Munir Anam Ahmad |
| author_sort | Saeeda Sadiq |
| collection | DOAJ |
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Objective: This cross-sectional study explores the complex effects of dengue fever on liver functions in individuals admitted to a Federal Government Polyclinic Hospital (PGMI), in Islamabad
Methods: This prospective cross-sectional study evaluated 60 children aged 1–12 years with confirmed dengue, categorized into dengue fever and dengue hemorrhagic fever groups, admitted to a hospital in Islamabad over six months in 2022. Liver function tests and clinical parameters were analyzed using SPSS to compare outcomes, with statistical significance set at p < 0.05.
Results: With a mean patient age of 7.23 ± 3.58 years and a male-to-female ratio of 1.22:1, our third-day results showed increased ALT in 50% of cases, AST in 71.7%, and STB in 13.3% of patients. By the seventh day, the corresponding percentages had increased to 68.3%, 96.7%, and 81.7%, respectively. Remarkably, AST exceeded ALT in 50% of cases on day three and in 43% of cases on day seven. Except for STB on day three (p = 0.435), mean ALT, AST, and STB levels were significantly higher in patients with Dengue Hemorrhagic Fever (DHF) on days three and 7 (p < 0.000).
Conclusion: This study demonstrated a significant correlation between liver function and dengue fever, with a more substantial effect observed in patients with plasma leakage or DHF. It becomes clear that monitoring liver function in dengue-infected individuals is essential for prompt intervention and improved clinical care.
Keywords: Hepatomegaly, Severe Dengue, Vomiting, Liver function tests.
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| format | Article |
| id | doaj-art-2072a6a6ef3044d2b5c965ddb7a59e35 |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-2072a6a6ef3044d2b5c965ddb7a59e352025-02-06T08:34:54ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702024-12-0128410.37939/jrmc.v28i4.2486Clinical Profile And Liver Functions In Dengue Fever Saeeda Sadiq0Amna MobeenNaveed AshrafFasih HashmiShahzad MunirAnam AhmadPMDC Objective: This cross-sectional study explores the complex effects of dengue fever on liver functions in individuals admitted to a Federal Government Polyclinic Hospital (PGMI), in Islamabad Methods: This prospective cross-sectional study evaluated 60 children aged 1–12 years with confirmed dengue, categorized into dengue fever and dengue hemorrhagic fever groups, admitted to a hospital in Islamabad over six months in 2022. Liver function tests and clinical parameters were analyzed using SPSS to compare outcomes, with statistical significance set at p < 0.05. Results: With a mean patient age of 7.23 ± 3.58 years and a male-to-female ratio of 1.22:1, our third-day results showed increased ALT in 50% of cases, AST in 71.7%, and STB in 13.3% of patients. By the seventh day, the corresponding percentages had increased to 68.3%, 96.7%, and 81.7%, respectively. Remarkably, AST exceeded ALT in 50% of cases on day three and in 43% of cases on day seven. Except for STB on day three (p = 0.435), mean ALT, AST, and STB levels were significantly higher in patients with Dengue Hemorrhagic Fever (DHF) on days three and 7 (p < 0.000). Conclusion: This study demonstrated a significant correlation between liver function and dengue fever, with a more substantial effect observed in patients with plasma leakage or DHF. It becomes clear that monitoring liver function in dengue-infected individuals is essential for prompt intervention and improved clinical care. Keywords: Hepatomegaly, Severe Dengue, Vomiting, Liver function tests. https://www.journalrmc.com/index.php/JRMC/article/view/2486 |
| spellingShingle | Saeeda Sadiq Amna Mobeen Naveed Ashraf Fasih Hashmi Shahzad Munir Anam Ahmad Clinical Profile And Liver Functions In Dengue Fever Journal of Rawalpindi Medical College |
| title | Clinical Profile And Liver Functions In Dengue Fever |
| title_full | Clinical Profile And Liver Functions In Dengue Fever |
| title_fullStr | Clinical Profile And Liver Functions In Dengue Fever |
| title_full_unstemmed | Clinical Profile And Liver Functions In Dengue Fever |
| title_short | Clinical Profile And Liver Functions In Dengue Fever |
| title_sort | clinical profile and liver functions in dengue fever |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2486 |
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