Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients
Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/613860 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565355697930240 |
|---|---|
| author | Inbal Dahan Evgeny Farber Nadia Thauho Nakhoul Nakhoul Adi Francis Mohamad Awawde Andrew P. Levy Daniel B. Kim-Shapiro Swati Basu Farid Nakhoul |
| author_facet | Inbal Dahan Evgeny Farber Nadia Thauho Nakhoul Nakhoul Adi Francis Mohamad Awawde Andrew P. Levy Daniel B. Kim-Shapiro Swati Basu Farid Nakhoul |
| author_sort | Inbal Dahan |
| collection | DOAJ |
| description | Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascular tone. We therefore set out to test the hypothesis that the Hp polymorphism may be a determinant of developing elevated s-PAP specifically in the DM state due to a decreased bioavailability of NO. To test our hypothesis we Hp typed and performed transthoracic echocardiography on a series of HD patients and stratified them into elevated and normal s-PAP groups and then evaluated whether there was a significant association between the Hp type, elevated s-PAP, and decreased NO bioavailability as defined by low plasma nitrite. We found a statistically significant interaction between the Hp type and DM on the prevalence of elevated s-PAP and lower mean nitrite levels with the combination of elevated s-PAP and low nitrite levels being significantly more prevalent in Hp 2-2 DM individuals. We conclude that the Hp 2 type is associated with elevated s-PAP levels and low plasma nitrite levels in HD patients specifically in the DM state. |
| format | Article |
| id | doaj-art-206e6e00561a4eb8a114bb4f26af05cc |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-206e6e00561a4eb8a114bb4f26af05cc2025-02-03T01:07:49ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/613860613860Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis PatientsInbal Dahan0Evgeny Farber1Nadia Thauho2Nakhoul Nakhoul3Adi Francis4Mohamad Awawde5Andrew P. Levy6Daniel B. Kim-Shapiro7Swati Basu8Farid Nakhoul9Diabetic Nephropathy Laboratory, The Baruch Padeh Poriya Medical Center, Faculty of Medicine in the Galilee, 15208 The Lower Galilee, IsraelDivision of Nephrology & Hypertension, The Baruch Padeh Poriya Medical Center, Faculty of Medicine in the Galilee, 15208 The Lower Galilee, IsraelDiabetic Nephropathy Laboratory, The Baruch Padeh Poriya Medical Center, Faculty of Medicine in the Galilee, 15208 The Lower Galilee, IsraelDivision of Nephrology & Hypertension, The Baruch Padeh Poriya Medical Center, Faculty of Medicine in the Galilee, 15208 The Lower Galilee, IsraelDivision of Vascular Medicine, Holy Family Hospital, 16234 Nazareth, IsraelDivision of Vascular Medicine, Holy Family Hospital, 16234 Nazareth, IsraelRappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096 Haifa, IsraelDepartment of Physics and Translational Science Center, Wake Forest University, Reynolda Campus, Winston-Salem, NC 27109, USADepartment of Physics and Translational Science Center, Wake Forest University, Reynolda Campus, Winston-Salem, NC 27109, USADiabetic Nephropathy Laboratory, The Baruch Padeh Poriya Medical Center, Faculty of Medicine in the Galilee, 15208 The Lower Galilee, IsraelElevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascular tone. We therefore set out to test the hypothesis that the Hp polymorphism may be a determinant of developing elevated s-PAP specifically in the DM state due to a decreased bioavailability of NO. To test our hypothesis we Hp typed and performed transthoracic echocardiography on a series of HD patients and stratified them into elevated and normal s-PAP groups and then evaluated whether there was a significant association between the Hp type, elevated s-PAP, and decreased NO bioavailability as defined by low plasma nitrite. We found a statistically significant interaction between the Hp type and DM on the prevalence of elevated s-PAP and lower mean nitrite levels with the combination of elevated s-PAP and low nitrite levels being significantly more prevalent in Hp 2-2 DM individuals. We conclude that the Hp 2 type is associated with elevated s-PAP levels and low plasma nitrite levels in HD patients specifically in the DM state.http://dx.doi.org/10.1155/2015/613860 |
| spellingShingle | Inbal Dahan Evgeny Farber Nadia Thauho Nakhoul Nakhoul Adi Francis Mohamad Awawde Andrew P. Levy Daniel B. Kim-Shapiro Swati Basu Farid Nakhoul Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients Journal of Diabetes Research |
| title | Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients |
| title_full | Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients |
| title_fullStr | Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients |
| title_full_unstemmed | Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients |
| title_short | Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients |
| title_sort | interaction between the haptoglobin 2 phenotype and diabetes mellitus on systolic pulmonary arterial pressure and nitric oxide bioavailability in hemodialysis patients |
| url | http://dx.doi.org/10.1155/2015/613860 |
| work_keys_str_mv | AT inbaldahan interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients AT evgenyfarber interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients AT nadiathauho interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients AT nakhoulnakhoul interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients AT adifrancis interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients AT mohamadawawde interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients AT andrewplevy interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients AT danielbkimshapiro interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients AT swatibasu interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients AT faridnakhoul interactionbetweenthehaptoglobin2phenotypeanddiabetesmellitusonsystolicpulmonaryarterialpressureandnitricoxidebioavailabilityinhemodialysispatients |