Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data.

Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data.

Real-time detection of the rates of metabolic flux, or exchange rates of endogenous enzymatic reactions, is now feasible in biological systems using Dynamic Nuclear Polarization Magnetic Resonance. Derivation of reaction rate kinetics from this technique typically requires multi-compartmental modeli...

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Main Authors: Deborah K Hill, Matthew R Orton, Erika Mariotti, Jessica K R Boult, Rafal Panek, Maysam Jafar, Harold G Parkes, Yann Jamin, Maria Falck Miniotis, Nada M S Al-Saffar, Mounia Beloueche-Babari, Simon P Robinson, Martin O Leach, Yuen-Li Chung, Thomas R Eykyn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0071996
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