Organ-based characterization of B cells in patients with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509033/full |
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| author | Yunan Wang Rui Zhao Qian Liang Shiwen Ni Mei Yang Liwei Qiu Juan Ji Zhifeng Gu Chen Dong |
| author_facet | Yunan Wang Rui Zhao Qian Liang Shiwen Ni Mei Yang Liwei Qiu Juan Ji Zhifeng Gu Chen Dong |
| author_sort | Yunan Wang |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system and disruption of immune tolerance, particularly through the abnormal activation of B lymphocytes and the production of excessive autoantibodies, lead to widespread inflammation and tissue damage, resulting in multi-organ impairment. Currently, there is no systematic review that examines the specificity of B cell characteristics and pathogenic mechanisms across various organs. This paper reviews current research on B cells in lupus patients and summarizes the distinct characteristics of B cells in different organs. By integrating clinical manifestations of organ damage in patients with a focus on the organ-specific features of B cells, we provide a new perspective on enhancing the efficacy of lupus-targeted B cell therapy strategies. |
| format | Article |
| id | doaj-art-20639f831bb1420abd357983e3e22eb0 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-20639f831bb1420abd357983e3e22eb02025-01-23T06:56:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15090331509033Organ-based characterization of B cells in patients with systemic lupus erythematosusYunan WangRui ZhaoQian LiangShiwen NiMei YangLiwei QiuJuan JiZhifeng GuChen DongSystemic lupus erythematosus (SLE) is a chronic, inflammatory, and progressive autoimmune disease. The unclear pathogenesis, high heterogeneity, and prolonged course of the disease present significant challenges for effective clinical management of lupus patients. Dysregulation of the immune system and disruption of immune tolerance, particularly through the abnormal activation of B lymphocytes and the production of excessive autoantibodies, lead to widespread inflammation and tissue damage, resulting in multi-organ impairment. Currently, there is no systematic review that examines the specificity of B cell characteristics and pathogenic mechanisms across various organs. This paper reviews current research on B cells in lupus patients and summarizes the distinct characteristics of B cells in different organs. By integrating clinical manifestations of organ damage in patients with a focus on the organ-specific features of B cells, we provide a new perspective on enhancing the efficacy of lupus-targeted B cell therapy strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509033/fullsystemic lupus erythematosusB cellorgan damageorgan specific featurestherapy strategies |
| spellingShingle | Yunan Wang Rui Zhao Qian Liang Shiwen Ni Mei Yang Liwei Qiu Juan Ji Zhifeng Gu Chen Dong Organ-based characterization of B cells in patients with systemic lupus erythematosus Frontiers in Immunology systemic lupus erythematosus B cell organ damage organ specific features therapy strategies |
| title | Organ-based characterization of B cells in patients with systemic lupus erythematosus |
| title_full | Organ-based characterization of B cells in patients with systemic lupus erythematosus |
| title_fullStr | Organ-based characterization of B cells in patients with systemic lupus erythematosus |
| title_full_unstemmed | Organ-based characterization of B cells in patients with systemic lupus erythematosus |
| title_short | Organ-based characterization of B cells in patients with systemic lupus erythematosus |
| title_sort | organ based characterization of b cells in patients with systemic lupus erythematosus |
| topic | systemic lupus erythematosus B cell organ damage organ specific features therapy strategies |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509033/full |
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