Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer
Abstract Objective To investigate the clinical efficacy of cytoreductive surgery in oligometastatic hormone-sensitive prostate cancer (omHSPC). Methods The basic characteristics, treatment strategies and long-term follow-up of 181 patients with omHSPC were retrospectively analyzed. All patients were...
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Springer
2025-01-01
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| Series: | Holistic Integrative Oncology |
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| Online Access: | https://doi.org/10.1007/s44178-024-00146-0 |
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| author | Feng Qi Yihang Xu Zicheng Xu Qing Zou |
| author_facet | Feng Qi Yihang Xu Zicheng Xu Qing Zou |
| author_sort | Feng Qi |
| collection | DOAJ |
| description | Abstract Objective To investigate the clinical efficacy of cytoreductive surgery in oligometastatic hormone-sensitive prostate cancer (omHSPC). Methods The basic characteristics, treatment strategies and long-term follow-up of 181 patients with omHSPC were retrospectively analyzed. All patients were divided into cytoreductive surgery group and no local therapy group according to the administration of cytoreductive surgery before progression to metastatic castration-resistant prostate cancer (mCRPC). Subsequently, our study explored the effect of cytoreductive surgery on CRPC-free survival in omHSPC patients. Results A total of 181 patients were enrolled in the study, including 48 patients who received cytoreductive surgery and 133 patients who did not receive local therapy. No significant differences were detected between the two groups regarding prostate-specific antigen (PSA) at the initial diagnosis (P = 0.194), the International Society of Urological Pathology (ISUP) grade group (P = 0.158), the treatment options during omHSPC (P = 0.090), common comorbidities (P = 0.649) and the number of metastases (P = 0.291). The proportions of patients with Tx stage (P = 0.027) and Nx stage (P = 0.027) in the no local therapy group were significantly higher than that in the cytoreductive group. After propensity score matching (PSM), it was found that cytoreductive surgery could significantly improve the CRPC-free survival of omHSPC patients (hazard ratio (HR) = 0.537, 95% confidence interval (CI) = 0.317–0.909, P = 0.016). Conclusion Cytoreductive surgery can significantly improve the CRPC-free survival of omHSPC patients. Additionally, large sample-size, prospective and randomized controlled studies are needed to validate the results of our study in the future. |
| format | Article |
| id | doaj-art-20548a67dc6b4cc5ab2d8f9bf4eed921 |
| institution | Kabale University |
| issn | 2731-4529 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Holistic Integrative Oncology |
| spelling | doaj-art-20548a67dc6b4cc5ab2d8f9bf4eed9212025-01-19T12:43:03ZengSpringerHolistic Integrative Oncology2731-45292025-01-01411510.1007/s44178-024-00146-0Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancerFeng Qi0Yihang Xu1Zicheng Xu2Qing Zou3Department of Urologic Surgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Affiliated Cancer Hospital of Nanjing Medical UniversityThe First Clinical Medical College, Nanjing Medical UniversityDepartment of Urologic Surgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Affiliated Cancer Hospital of Nanjing Medical UniversityDepartment of Urologic Surgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Affiliated Cancer Hospital of Nanjing Medical UniversityAbstract Objective To investigate the clinical efficacy of cytoreductive surgery in oligometastatic hormone-sensitive prostate cancer (omHSPC). Methods The basic characteristics, treatment strategies and long-term follow-up of 181 patients with omHSPC were retrospectively analyzed. All patients were divided into cytoreductive surgery group and no local therapy group according to the administration of cytoreductive surgery before progression to metastatic castration-resistant prostate cancer (mCRPC). Subsequently, our study explored the effect of cytoreductive surgery on CRPC-free survival in omHSPC patients. Results A total of 181 patients were enrolled in the study, including 48 patients who received cytoreductive surgery and 133 patients who did not receive local therapy. No significant differences were detected between the two groups regarding prostate-specific antigen (PSA) at the initial diagnosis (P = 0.194), the International Society of Urological Pathology (ISUP) grade group (P = 0.158), the treatment options during omHSPC (P = 0.090), common comorbidities (P = 0.649) and the number of metastases (P = 0.291). The proportions of patients with Tx stage (P = 0.027) and Nx stage (P = 0.027) in the no local therapy group were significantly higher than that in the cytoreductive group. After propensity score matching (PSM), it was found that cytoreductive surgery could significantly improve the CRPC-free survival of omHSPC patients (hazard ratio (HR) = 0.537, 95% confidence interval (CI) = 0.317–0.909, P = 0.016). Conclusion Cytoreductive surgery can significantly improve the CRPC-free survival of omHSPC patients. Additionally, large sample-size, prospective and randomized controlled studies are needed to validate the results of our study in the future.https://doi.org/10.1007/s44178-024-00146-0Prostate cancerOligometastaticHormone sensitiveCytoreductive surgery |
| spellingShingle | Feng Qi Yihang Xu Zicheng Xu Qing Zou Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer Holistic Integrative Oncology Prostate cancer Oligometastatic Hormone sensitive Cytoreductive surgery |
| title | Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer |
| title_full | Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer |
| title_fullStr | Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer |
| title_full_unstemmed | Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer |
| title_short | Clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone-sensitive prostate cancer |
| title_sort | clinical efficacy of cytoreductive radical prostatectomy in the treatment of oligometastatic hormone sensitive prostate cancer |
| topic | Prostate cancer Oligometastatic Hormone sensitive Cytoreductive surgery |
| url | https://doi.org/10.1007/s44178-024-00146-0 |
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