Application of low-coverage whole-genome sequencing technology in risk stratification of colorectal adenomas

Application of low-coverage whole-genome sequencing technology in risk stratification of colorectal adenomas

ObjectiveThe diagnosis of precancerous lesions of colorectal cancer (CRC) presents significant challenges in clinical practice. In this study, we conducted a clinical investigation using the UCAD technique after analyzing chromosomal copy number variations (CNVs) in formalin-fixed, paraffin-embedded...

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Bibliographic Details
Main Authors: Guo Zhili, Xue Yuyue, Yu Fang, Ren Dianqun, Zhang Qin, Liu Jie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
colorectal adenoma
whole-genome sequencing
tubular adenoma
villous adenoma
chromosomal instability
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1591548/full
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