Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients
Diabetic nephropathy (DN) is one of the major chronic complications of diabetes. Genetic polymorphism of Apolipoprotein E (ApoE) has been proposed to participating in DN. The purpose of the study was to evaluate the relationship between ApoE genetic polymorphism and the presence of DN in Chinese typ...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3560920 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564109124567040 |
|---|---|
| author | YongWei Jiang Liang Ma ChengWu Han Qian Liu Xiao Cong YaPing Xu TingTing Zhao Ping Li YongTong Cao |
| author_facet | YongWei Jiang Liang Ma ChengWu Han Qian Liu Xiao Cong YaPing Xu TingTing Zhao Ping Li YongTong Cao |
| author_sort | YongWei Jiang |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is one of the major chronic complications of diabetes. Genetic polymorphism of Apolipoprotein E (ApoE) has been proposed to participating in DN. The purpose of the study was to evaluate the relationship between ApoE genetic polymorphism and the presence of DN in Chinese type 2 diabetic patients. We studied 845 diabetic patients who were divided into DN group (n=429) and control group (n=416). ApoE genotype was determined by ApoE genotyping chip and the plasmatic biochemical characterization was performed on all subjects. There were differences (P<0.001) in HbA1c, creatinine, and urinary albumin between the two groups. The ApoE ε2 allelic frequency was 7.69% in DN group versus 3.49% in control group (OR = 2.22, 95% CI = 1.41–3.47, and P<0.05), as expected, ApoE E2/E2 and E2/E3 genotype frequency were higher in DN group (13.75% versus 6.49%, P<0.05). The ApoE ε4 allelic frequency was 7.93% in DN group versus 11.54% in control group (OR = 0.70, 95% CI = 0.50–0.97, and P<0.05), and DN group presented a lower frequency of ApoE E3/E4 and E4/E4 genotype frequency (14.91% versus 19.96%, P<0.05). These results suggest ApoE ε2 allele may be a risk factor; however ApoE ε4 allele may play a protective role of DN in Chinese type 2 diabetic patients. |
| format | Article |
| id | doaj-art-204e15062aa7467da7f22a5d54231ee9 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-204e15062aa7467da7f22a5d54231ee92025-02-03T01:11:44ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/35609203560920Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic PatientsYongWei Jiang0Liang Ma1ChengWu Han2Qian Liu3Xiao Cong4YaPing Xu5TingTing Zhao6Ping Li7YongTong Cao8Clinical Laboratory, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Beijing, ChinaClinical Laboratory, China-Japan Friendship Hospital, Beijing, ChinaClinical Laboratory, China-Japan Friendship Hospital, Beijing, ChinaClinical Laboratory, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Pathophysiology, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, ChinaBeijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Beijing, ChinaClinical Laboratory, China-Japan Friendship Hospital, Beijing, ChinaDiabetic nephropathy (DN) is one of the major chronic complications of diabetes. Genetic polymorphism of Apolipoprotein E (ApoE) has been proposed to participating in DN. The purpose of the study was to evaluate the relationship between ApoE genetic polymorphism and the presence of DN in Chinese type 2 diabetic patients. We studied 845 diabetic patients who were divided into DN group (n=429) and control group (n=416). ApoE genotype was determined by ApoE genotyping chip and the plasmatic biochemical characterization was performed on all subjects. There were differences (P<0.001) in HbA1c, creatinine, and urinary albumin between the two groups. The ApoE ε2 allelic frequency was 7.69% in DN group versus 3.49% in control group (OR = 2.22, 95% CI = 1.41–3.47, and P<0.05), as expected, ApoE E2/E2 and E2/E3 genotype frequency were higher in DN group (13.75% versus 6.49%, P<0.05). The ApoE ε4 allelic frequency was 7.93% in DN group versus 11.54% in control group (OR = 0.70, 95% CI = 0.50–0.97, and P<0.05), and DN group presented a lower frequency of ApoE E3/E4 and E4/E4 genotype frequency (14.91% versus 19.96%, P<0.05). These results suggest ApoE ε2 allele may be a risk factor; however ApoE ε4 allele may play a protective role of DN in Chinese type 2 diabetic patients.http://dx.doi.org/10.1155/2017/3560920 |
| spellingShingle | YongWei Jiang Liang Ma ChengWu Han Qian Liu Xiao Cong YaPing Xu TingTing Zhao Ping Li YongTong Cao Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients Journal of Diabetes Research |
| title | Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients |
| title_full | Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients |
| title_fullStr | Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients |
| title_full_unstemmed | Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients |
| title_short | Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients |
| title_sort | effects of apolipoprotein e isoforms in diabetic nephropathy of chinese type 2 diabetic patients |
| url | http://dx.doi.org/10.1155/2017/3560920 |
| work_keys_str_mv | AT yongweijiang effectsofapolipoproteineisoformsindiabeticnephropathyofchinesetype2diabeticpatients AT liangma effectsofapolipoproteineisoformsindiabeticnephropathyofchinesetype2diabeticpatients AT chengwuhan effectsofapolipoproteineisoformsindiabeticnephropathyofchinesetype2diabeticpatients AT qianliu effectsofapolipoproteineisoformsindiabeticnephropathyofchinesetype2diabeticpatients AT xiaocong effectsofapolipoproteineisoformsindiabeticnephropathyofchinesetype2diabeticpatients AT yapingxu effectsofapolipoproteineisoformsindiabeticnephropathyofchinesetype2diabeticpatients AT tingtingzhao effectsofapolipoproteineisoformsindiabeticnephropathyofchinesetype2diabeticpatients AT pingli effectsofapolipoproteineisoformsindiabeticnephropathyofchinesetype2diabeticpatients AT yongtongcao effectsofapolipoproteineisoformsindiabeticnephropathyofchinesetype2diabeticpatients |