Phospholipase A2 Activity in Gingival Crevicular Fluid from Patients with Periodontal Disease: A possible Marker of Disease Activity
The activity of phospholipase A2 in human gingival crevicular fluid (GCF) associated with periodontal disease was demonstrated. Based upon the presence or absence of bleeding on probing (BOP), which is a marker for the disease activity, there were higher levels of the enzyme activity in BOP positive...
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| Format: | Article |
| Language: | English |
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Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000037 |
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| author | H. Ishida H. Shinohara T. Nagata S. Nishikawa Y. Wakano |
| author_facet | H. Ishida H. Shinohara T. Nagata S. Nishikawa Y. Wakano |
| author_sort | H. Ishida |
| collection | DOAJ |
| description | The activity of phospholipase A2 in human gingival crevicular fluid
(GCF) associated with periodontal disease was demonstrated. Based
upon the presence or absence of bleeding on probing (BOP), which is
a marker for the disease activity, there were higher levels of the
enzyme activity in BOP positive, than in negative sites. When the
BOP positive sites became negative after periodontal therapy, the
enzyme activity decreased dramatically to almost undetectable
levels. There were no significant differences between the activity
before and after treatment when the BOP positive sites remained
unchanged. These results suggest that the activity in GCF reflects
periodontal disease conditions and that it can be used as a marker
for disease activity. |
| format | Article |
| id | doaj-art-204474dc15fc4e0d85813aba26cb7827 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-204474dc15fc4e0d85813aba26cb78272025-02-03T01:30:49ZengWileyMediators of Inflammation0962-93511466-18611994-01-0131172110.1155/S0962935194000037Phospholipase A2 Activity in Gingival Crevicular Fluid from Patients with Periodontal Disease: A possible Marker of Disease ActivityH. Ishida0H. Shinohara1T. Nagata2S. Nishikawa3Y. Wakano4Department of Periodontology and Endodontology, School of Dentistry, Tokushima University, 3 Kuramoto-cho, Tokushima, Tokushima 770, JapanDepartment of Periodontology and Endodontology, School of Dentistry, Tokushima University, 3 Kuramoto-cho, Tokushima, Tokushima 770, JapanDepartment of Periodontology and Endodontology, School of Dentistry, Tokushima University, 3 Kuramoto-cho, Tokushima, Tokushima 770, JapanDepartment of Periodontology and Endodontology, School of Dentistry, Tokushima University, 3 Kuramoto-cho, Tokushima, Tokushima 770, JapanDepartment of Periodontology and Endodontology, School of Dentistry, Tokushima University, 3 Kuramoto-cho, Tokushima, Tokushima 770, JapanThe activity of phospholipase A2 in human gingival crevicular fluid (GCF) associated with periodontal disease was demonstrated. Based upon the presence or absence of bleeding on probing (BOP), which is a marker for the disease activity, there were higher levels of the enzyme activity in BOP positive, than in negative sites. When the BOP positive sites became negative after periodontal therapy, the enzyme activity decreased dramatically to almost undetectable levels. There were no significant differences between the activity before and after treatment when the BOP positive sites remained unchanged. These results suggest that the activity in GCF reflects periodontal disease conditions and that it can be used as a marker for disease activity.http://dx.doi.org/10.1155/S0962935194000037 |
| spellingShingle | H. Ishida H. Shinohara T. Nagata S. Nishikawa Y. Wakano Phospholipase A2 Activity in Gingival Crevicular Fluid from Patients with Periodontal Disease: A possible Marker of Disease Activity Mediators of Inflammation |
| title | Phospholipase A2 Activity in Gingival Crevicular Fluid from Patients
with Periodontal Disease: A possible Marker of Disease Activity |
| title_full | Phospholipase A2 Activity in Gingival Crevicular Fluid from Patients
with Periodontal Disease: A possible Marker of Disease Activity |
| title_fullStr | Phospholipase A2 Activity in Gingival Crevicular Fluid from Patients
with Periodontal Disease: A possible Marker of Disease Activity |
| title_full_unstemmed | Phospholipase A2 Activity in Gingival Crevicular Fluid from Patients
with Periodontal Disease: A possible Marker of Disease Activity |
| title_short | Phospholipase A2 Activity in Gingival Crevicular Fluid from Patients
with Periodontal Disease: A possible Marker of Disease Activity |
| title_sort | phospholipase a2 activity in gingival crevicular fluid from patients with periodontal disease a possible marker of disease activity |
| url | http://dx.doi.org/10.1155/S0962935194000037 |
| work_keys_str_mv | AT hishida phospholipasea2activityingingivalcrevicularfluidfrompatientswithperiodontaldiseaseapossiblemarkerofdiseaseactivity AT hshinohara phospholipasea2activityingingivalcrevicularfluidfrompatientswithperiodontaldiseaseapossiblemarkerofdiseaseactivity AT tnagata phospholipasea2activityingingivalcrevicularfluidfrompatientswithperiodontaldiseaseapossiblemarkerofdiseaseactivity AT snishikawa phospholipasea2activityingingivalcrevicularfluidfrompatientswithperiodontaldiseaseapossiblemarkerofdiseaseactivity AT ywakano phospholipasea2activityingingivalcrevicularfluidfrompatientswithperiodontaldiseaseapossiblemarkerofdiseaseactivity |