Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients
Objective: To evaluate the systemic immune-inflammation (SII) index in patients with rheumatoid arthritis (RA) stratified by systemic inflammatory status. Methods: Seropositive patients with RA (n=58) were divided into two groups based on serum hs-C-reactive protein (hs-CRP) levels: RA patients with...
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Galenos Publishing House
2024-09-01
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| Series: | Medeniyet Medical Journal |
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| author | Amela DERVISEVIC Almir FAJKIC Elmedina JAHIC Lejla DERVISEVIC Zurifa AJANOVIC Enisa ADEMOVIC Asija ZACIRAGIC |
| author_facet | Amela DERVISEVIC Almir FAJKIC Elmedina JAHIC Lejla DERVISEVIC Zurifa AJANOVIC Enisa ADEMOVIC Asija ZACIRAGIC |
| author_sort | Amela DERVISEVIC |
| collection | DOAJ |
| description | Objective: To evaluate the systemic immune-inflammation (SII) index in patients with rheumatoid arthritis (RA) stratified by systemic inflammatory status.
Methods: Seropositive patients with RA (n=58) were divided into two groups based on serum hs-C-reactive protein (hs-CRP) levels: RA patients with hs-CRP levels of at or 3 mg/L or above (high systemic inflammatory status; n=38) and RA patients with hs-CRP levels of less than 3 mg/L (low systemic inflammatory status; n=20). The control group comprised 31 healthy individuals. Blood samples were tested for the next parameters: leukocytes, neutrophilic granulocytes, lymphocytes, thrombocytes [platelet (PLT)], high-sensitivity hs-CRP, sed rate [erythrocyte sedimentation rate (ESR)], neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). The SII index was derived as Neu x PLT/Lym.
Results: In patients with RA, the SII index was elevated compared with that of healthy individuals and positively correlated with hs-CRP, erythrocyte sedimentation rate, NLR, MLR, PLR, tender joint count, and swollen-to-tender joint count ratio. Patients with RA who had hs-CRP levels of 3 mg/L above exhibited a statistically significant increase in the SII compared with those with hs-CRP levels below 3 mg/L. Additionally, within the cohort of RA patients with hs-CRP levels at or above 3 mg/L, a positive correlation was found between the SII index and both NLR and PLR. The SII index was positively correlated with NLR, MLR, and PLR in RA patients with hs-CRP levels below 3 mg/L. The cut-off point of the SII index for distinguishing between RA cases with hs-CRP levels 3 mg/L and those with hs-CRP levels 3 mg/L or higher was ≥323.4, with a sensitivity of 77.6% and a specificity of 54.8%.
Conclusions: The serum SII index can be a potentially useful marker for evaluating the inflammatory process and clinical progression of RA. |
| format | Article |
| id | doaj-art-2042e3095438475fa7b1227e093ca9ed |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Galenos Publishing House |
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| series | Medeniyet Medical Journal |
| spelling | doaj-art-2042e3095438475fa7b1227e093ca9ed2025-01-29T10:22:46ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062024-09-0139318319110.4274/MMJ.galenos.2024.60533MEDJ-60533Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis PatientsAmela DERVISEVIC0Almir FAJKIC1Elmedina JAHIC2Lejla DERVISEVIC3Zurifa AJANOVIC4Enisa ADEMOVIC5Asija ZACIRAGIC6University of Sarajevo Faculty of Medicine, Department of Human Physiology, Sarajevo, Bosnia and HerzegovinaUniversity of Sarajevo Faculty of Medicine, Department of Pathophysiology, Sarajevo, Bosnia and HerzegovinaClinical Center University of Sarajevo, Clinic for Heart, Blood Vessel and Rheumatic Diseases, Sarajevo, Bosnia and HerzegovinaUniversity of Sarajevo Faculty of Medicine, Department of Anatomy, Sarajevo, Bosnia and HerzegovinaUniversity of Sarajevo Faculty of Medicine, Department of Anatomy, Sarajevo, Bosnia and HerzegovinaUniversity of Sarajevo Faculty of Medicine, Department of Epidemiology and Biostatistics, Sarajevo, Bosnia and HerzegovinaUniversity of Sarajevo Faculty of Medicine, Department of Human Physiology, Sarajevo, Bosnia and HerzegovinaObjective: To evaluate the systemic immune-inflammation (SII) index in patients with rheumatoid arthritis (RA) stratified by systemic inflammatory status. Methods: Seropositive patients with RA (n=58) were divided into two groups based on serum hs-C-reactive protein (hs-CRP) levels: RA patients with hs-CRP levels of at or 3 mg/L or above (high systemic inflammatory status; n=38) and RA patients with hs-CRP levels of less than 3 mg/L (low systemic inflammatory status; n=20). The control group comprised 31 healthy individuals. Blood samples were tested for the next parameters: leukocytes, neutrophilic granulocytes, lymphocytes, thrombocytes [platelet (PLT)], high-sensitivity hs-CRP, sed rate [erythrocyte sedimentation rate (ESR)], neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). The SII index was derived as Neu x PLT/Lym. Results: In patients with RA, the SII index was elevated compared with that of healthy individuals and positively correlated with hs-CRP, erythrocyte sedimentation rate, NLR, MLR, PLR, tender joint count, and swollen-to-tender joint count ratio. Patients with RA who had hs-CRP levels of 3 mg/L above exhibited a statistically significant increase in the SII compared with those with hs-CRP levels below 3 mg/L. Additionally, within the cohort of RA patients with hs-CRP levels at or above 3 mg/L, a positive correlation was found between the SII index and both NLR and PLR. The SII index was positively correlated with NLR, MLR, and PLR in RA patients with hs-CRP levels below 3 mg/L. The cut-off point of the SII index for distinguishing between RA cases with hs-CRP levels 3 mg/L and those with hs-CRP levels 3 mg/L or higher was ≥323.4, with a sensitivity of 77.6% and a specificity of 54.8%. Conclusions: The serum SII index can be a potentially useful marker for evaluating the inflammatory process and clinical progression of RA.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-60533systemic immune-inflammation indexinflammationhs-crprheumatoid arthritis |
| spellingShingle | Amela DERVISEVIC Almir FAJKIC Elmedina JAHIC Lejla DERVISEVIC Zurifa AJANOVIC Enisa ADEMOVIC Asija ZACIRAGIC Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients Medeniyet Medical Journal systemic immune-inflammation index inflammation hs-crp rheumatoid arthritis |
| title | Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients |
| title_full | Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients |
| title_fullStr | Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients |
| title_full_unstemmed | Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients |
| title_short | Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients |
| title_sort | systemic immune inflammation index in evaluation of inflammation in rheumatoid arthritis patients |
| topic | systemic immune-inflammation index inflammation hs-crp rheumatoid arthritis |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-60533 |
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