Bioanalytical method development, in-vivo pharmacokinetic evaluation, ex-vivo platelet aggregation inhibition activity of a novel solid dispersion formulation of ticagrelor

Bioanalytical method development, in-vivo pharmacokinetic evaluation, ex-vivo platelet aggregation inhibition activity of a novel solid dispersion formulation of ticagrelor

BackgroundTicagrelor, a potential antithrombotic drug indicated for cardiovascular events with acute coronary syndrome, has been restricted from its oral use due to poor aqueous solubility. The present investigation aimed to develop validated bioanalytical method for the analysis of plasma samples f...

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Bibliographic Details
Main Authors: Abhishek Srivastava, Simrata Bedi, Abhishesh Kumar Mehata, Datta Maroti Pawde, Ketan Vinayakrao Hatware, Mohammad Ahmad Khan, M. S. Muthu, Uma Bhandari
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Medical Technology
Subjects:
ticagrelor
antithrombotic agent
solid dispersion
bioavailability
pharmacokinetic
Online Access:https://www.frontiersin.org/articles/10.3389/fmedt.2025.1499189/full
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