Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient’s request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupiluma...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/6381670 |
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| _version_ | 1832567429816909824 |
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| author | Masaya Iwamuro Toshi Murakami Takehiro Tanaka Shohei Oka Seiji Kawano Yoshiro Kawahara Hiroyuki Okada |
| author_facet | Masaya Iwamuro Toshi Murakami Takehiro Tanaka Shohei Oka Seiji Kawano Yoshiro Kawahara Hiroyuki Okada |
| author_sort | Masaya Iwamuro |
| collection | DOAJ |
| description | A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient’s request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupilumab treatment revealed gastric ulcers; subsequently, eosinophilic gastritis was diagnosed from biopsy examinations. The gastric lesions were resolved by steroid administration. This case report underscores that eosinophil-associated gastrointestinal diseases should be considered in the differential diagnosis of gastric lesions occurring in patients who were treated with dupilumab. |
| format | Article |
| id | doaj-art-202eb99e32464e5e9b78aa85c02be8dd |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-202eb99e32464e5e9b78aa85c02be8dd2025-02-03T01:01:27ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362020-01-01202010.1155/2020/63816706381670Eosinophilic Gastritis in a Patient Previously Treated with DupilumabMasaya Iwamuro0Toshi Murakami1Takehiro Tanaka2Shohei Oka3Seiji Kawano4Yoshiro Kawahara5Hiroyuki Okada6Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanSatsuki Naika Clinic, Okayama 703-8258, JapanDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Practical Gastrointestinal Endoscopy, Okayama University Hospital, Okayama 700-8558, JapanDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanA 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient’s request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupilumab treatment revealed gastric ulcers; subsequently, eosinophilic gastritis was diagnosed from biopsy examinations. The gastric lesions were resolved by steroid administration. This case report underscores that eosinophil-associated gastrointestinal diseases should be considered in the differential diagnosis of gastric lesions occurring in patients who were treated with dupilumab.http://dx.doi.org/10.1155/2020/6381670 |
| spellingShingle | Masaya Iwamuro Toshi Murakami Takehiro Tanaka Shohei Oka Seiji Kawano Yoshiro Kawahara Hiroyuki Okada Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab Case Reports in Gastrointestinal Medicine |
| title | Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab |
| title_full | Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab |
| title_fullStr | Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab |
| title_full_unstemmed | Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab |
| title_short | Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab |
| title_sort | eosinophilic gastritis in a patient previously treated with dupilumab |
| url | http://dx.doi.org/10.1155/2020/6381670 |
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