Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab

A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient’s request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupiluma...

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Main Authors: Masaya Iwamuro, Toshi Murakami, Takehiro Tanaka, Shohei Oka, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Case Reports in Gastrointestinal Medicine
Online Access:http://dx.doi.org/10.1155/2020/6381670
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author Masaya Iwamuro
Toshi Murakami
Takehiro Tanaka
Shohei Oka
Seiji Kawano
Yoshiro Kawahara
Hiroyuki Okada
author_facet Masaya Iwamuro
Toshi Murakami
Takehiro Tanaka
Shohei Oka
Seiji Kawano
Yoshiro Kawahara
Hiroyuki Okada
author_sort Masaya Iwamuro
collection DOAJ
description A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient’s request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupilumab treatment revealed gastric ulcers; subsequently, eosinophilic gastritis was diagnosed from biopsy examinations. The gastric lesions were resolved by steroid administration. This case report underscores that eosinophil-associated gastrointestinal diseases should be considered in the differential diagnosis of gastric lesions occurring in patients who were treated with dupilumab.
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institution Kabale University
issn 2090-6528
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language English
publishDate 2020-01-01
publisher Wiley
record_format Article
series Case Reports in Gastrointestinal Medicine
spelling doaj-art-202eb99e32464e5e9b78aa85c02be8dd2025-02-03T01:01:27ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362020-01-01202010.1155/2020/63816706381670Eosinophilic Gastritis in a Patient Previously Treated with DupilumabMasaya Iwamuro0Toshi Murakami1Takehiro Tanaka2Shohei Oka3Seiji Kawano4Yoshiro Kawahara5Hiroyuki Okada6Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanSatsuki Naika Clinic, Okayama 703-8258, JapanDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Practical Gastrointestinal Endoscopy, Okayama University Hospital, Okayama 700-8558, JapanDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, JapanA 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient’s request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupilumab treatment revealed gastric ulcers; subsequently, eosinophilic gastritis was diagnosed from biopsy examinations. The gastric lesions were resolved by steroid administration. This case report underscores that eosinophil-associated gastrointestinal diseases should be considered in the differential diagnosis of gastric lesions occurring in patients who were treated with dupilumab.http://dx.doi.org/10.1155/2020/6381670
spellingShingle Masaya Iwamuro
Toshi Murakami
Takehiro Tanaka
Shohei Oka
Seiji Kawano
Yoshiro Kawahara
Hiroyuki Okada
Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
Case Reports in Gastrointestinal Medicine
title Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_full Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_fullStr Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_full_unstemmed Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_short Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_sort eosinophilic gastritis in a patient previously treated with dupilumab
url http://dx.doi.org/10.1155/2020/6381670
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