Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies
Atherosclerosis, the primary cause of coronary artery disease (CAD), remains a leading global cause of mortality. It is characterized by the accumulation of cholesterol-rich plaques and inflammation, which narrow the coronary arteries and increase the risk of rupture. To elucidate this complex biolo...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1548355/full |
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| author | Rui Gao Rui Gao Rui Gao Meilin Liu Meilin Liu Meilin Liu Haoyi Yang Haoyi Yang Haoyi Yang Yuhan Shen Yuhan Shen Yuhan Shen Ni Xia Ni Xia Ni Xia |
| author_facet | Rui Gao Rui Gao Rui Gao Meilin Liu Meilin Liu Meilin Liu Haoyi Yang Haoyi Yang Haoyi Yang Yuhan Shen Yuhan Shen Yuhan Shen Ni Xia Ni Xia Ni Xia |
| author_sort | Rui Gao |
| collection | DOAJ |
| description | Atherosclerosis, the primary cause of coronary artery disease (CAD), remains a leading global cause of mortality. It is characterized by the accumulation of cholesterol-rich plaques and inflammation, which narrow the coronary arteries and increase the risk of rupture. To elucidate this complex biological process and improve therapeutic strategies, CAD has been extensively explored from an epigenetic perspective over the past two decades. Epigenetics is a field investigating heritable alterations in gene expression without DNA sequence changes, such as DNA methylation, histone modifications, and non-coding RNAs. Increasing evidence has indicated that the development of CAD is significantly influenced by epigenetic changes. Meanwhile, the impact of epigenetics in CAD is now transitioning from pathophysiology to therapeutics. Focusing on the key epigenetic enzymes and their target genes will help to facilitate the diagnosis and treatment of CAD. This review synthesizes novel epigenetic insights into CAD, addressing the pathological processes, key molecular mechanisms, and potential biomarkers. Furthermore, we discuss emerging therapeutic strategies targeting epigenetic pathways. By focusing on pivotal enzymes and their associated genes, this work aims to advance CAD diagnostics and interventions. |
| format | Article |
| id | doaj-art-2028b5cf72a04e9db0720a6c808b51b3 |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-2028b5cf72a04e9db0720a6c808b51b32025-01-31T05:10:22ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-01-011210.3389/fmolb.2025.15483551548355Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapiesRui Gao0Rui Gao1Rui Gao2Meilin Liu3Meilin Liu4Meilin Liu5Haoyi Yang6Haoyi Yang7Haoyi Yang8Yuhan Shen9Yuhan Shen10Yuhan Shen11Ni Xia12Ni Xia13Ni Xia14Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaAtherosclerosis, the primary cause of coronary artery disease (CAD), remains a leading global cause of mortality. It is characterized by the accumulation of cholesterol-rich plaques and inflammation, which narrow the coronary arteries and increase the risk of rupture. To elucidate this complex biological process and improve therapeutic strategies, CAD has been extensively explored from an epigenetic perspective over the past two decades. Epigenetics is a field investigating heritable alterations in gene expression without DNA sequence changes, such as DNA methylation, histone modifications, and non-coding RNAs. Increasing evidence has indicated that the development of CAD is significantly influenced by epigenetic changes. Meanwhile, the impact of epigenetics in CAD is now transitioning from pathophysiology to therapeutics. Focusing on the key epigenetic enzymes and their target genes will help to facilitate the diagnosis and treatment of CAD. This review synthesizes novel epigenetic insights into CAD, addressing the pathological processes, key molecular mechanisms, and potential biomarkers. Furthermore, we discuss emerging therapeutic strategies targeting epigenetic pathways. By focusing on pivotal enzymes and their associated genes, this work aims to advance CAD diagnostics and interventions.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1548355/fullepigeneticscoronary artery diseaseatherosclerosisDNA methylationhistone modificationsnon-coding RNAs |
| spellingShingle | Rui Gao Rui Gao Rui Gao Meilin Liu Meilin Liu Meilin Liu Haoyi Yang Haoyi Yang Haoyi Yang Yuhan Shen Yuhan Shen Yuhan Shen Ni Xia Ni Xia Ni Xia Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies Frontiers in Molecular Biosciences epigenetics coronary artery disease atherosclerosis DNA methylation histone modifications non-coding RNAs |
| title | Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies |
| title_full | Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies |
| title_fullStr | Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies |
| title_full_unstemmed | Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies |
| title_short | Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies |
| title_sort | epigenetic regulation in coronary artery disease from mechanisms to emerging therapies |
| topic | epigenetics coronary artery disease atherosclerosis DNA methylation histone modifications non-coding RNAs |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1548355/full |
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