The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women
Cervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, a major risk factor for cervical cancer. This study aims to investigate the relationship between cervicovaginal infections, HPV infection, and CIN development in 94 Rom...
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2025-01-01
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| author | Anca Daniela Brăila Cristian-Viorel Poalelungi Cristina-Crenguţa Albu Constantin Marian Damian Laurențiu Mihai Dȋră Andreea-Mariana Bănățeanu Claudia Florina Bogdan-Andreescu |
| author_facet | Anca Daniela Brăila Cristian-Viorel Poalelungi Cristina-Crenguţa Albu Constantin Marian Damian Laurențiu Mihai Dȋră Andreea-Mariana Bănățeanu Claudia Florina Bogdan-Andreescu |
| author_sort | Anca Daniela Brăila |
| collection | DOAJ |
| description | Cervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, a major risk factor for cervical cancer. This study aims to investigate the relationship between cervicovaginal infections, HPV infection, and CIN development in 94 Romanian women with cervical lesions. Comprehensive assessments included HPV genotyping, cytology, colposcopy, and histopathology. In 53.20% of cases, vaginal infections were identified, with <i>Candida albicans</i> most frequently associated with HPV. Histopathology revealed 48.94% low-grade CIN, 42.55% high-grade CIN, and 8.51% invasive carcinoma. There was a strong correlation between high-risk HPV types (especially HPV 16 and 18), colposcopic findings, histopathology, and age. This study emphasizes the mutual effect of cervicovaginal infections and HPV infection in increasing the risk of developing CIN and cervical cancer among Romanian women. Persistent infection with high-risk HPV types, particularly HPV 16 and 18, has been confirmed as a primary driver of CIN and cervical cancer progression. |
| format | Article |
| id | doaj-art-20245932384d41c7be29887bdaf5b50d |
| institution | Kabale University |
| issn | 2079-9721 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Diseases |
| spelling | doaj-art-20245932384d41c7be29887bdaf5b50d2025-01-24T13:29:16ZengMDPI AGDiseases2079-97212025-01-011311810.3390/diseases13010018The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian WomenAnca Daniela Brăila0Cristian-Viorel Poalelungi1Cristina-Crenguţa Albu2Constantin Marian Damian3Laurențiu Mihai Dȋră4Andreea-Mariana Bănățeanu5Claudia Florina Bogdan-Andreescu6Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Genetics, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Speciality Disciplines, “Titu Maiorescu” University, 031593 Bucharest, RomaniaDepartment of Speciality Disciplines, “Titu Maiorescu” University, 031593 Bucharest, RomaniaCervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, a major risk factor for cervical cancer. This study aims to investigate the relationship between cervicovaginal infections, HPV infection, and CIN development in 94 Romanian women with cervical lesions. Comprehensive assessments included HPV genotyping, cytology, colposcopy, and histopathology. In 53.20% of cases, vaginal infections were identified, with <i>Candida albicans</i> most frequently associated with HPV. Histopathology revealed 48.94% low-grade CIN, 42.55% high-grade CIN, and 8.51% invasive carcinoma. There was a strong correlation between high-risk HPV types (especially HPV 16 and 18), colposcopic findings, histopathology, and age. This study emphasizes the mutual effect of cervicovaginal infections and HPV infection in increasing the risk of developing CIN and cervical cancer among Romanian women. Persistent infection with high-risk HPV types, particularly HPV 16 and 18, has been confirmed as a primary driver of CIN and cervical cancer progression.https://www.mdpi.com/2079-9721/13/1/18cervical intraepithelial neoplasiahuman papillomaviruscervicovaginal infection |
| spellingShingle | Anca Daniela Brăila Cristian-Viorel Poalelungi Cristina-Crenguţa Albu Constantin Marian Damian Laurențiu Mihai Dȋră Andreea-Mariana Bănățeanu Claudia Florina Bogdan-Andreescu The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women Diseases cervical intraepithelial neoplasia human papillomavirus cervicovaginal infection |
| title | The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women |
| title_full | The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women |
| title_fullStr | The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women |
| title_full_unstemmed | The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women |
| title_short | The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women |
| title_sort | relationship between cervicovaginal infection human papillomavirus infection and cervical intraepithelial neoplasia in romanian women |
| topic | cervical intraepithelial neoplasia human papillomavirus cervicovaginal infection |
| url | https://www.mdpi.com/2079-9721/13/1/18 |
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