Characterization of Esocid Herpesvirus 1 (EsHV1) from Europe
During routine sampling of northern pike, a male <i>Esox lucius</i> with circular blue-metallic granular spots mainly located on the head and back was identified. Histological investigations presented multifocally thickened epidermis rich in basophilic large structures with a granulated...
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MDPI AG
2025-01-01
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| author | Mikael Leijon Charlotte Axén Fereshteh Banihashem Tobias Lilja Petter Tibblin Björn David Persson |
| author_facet | Mikael Leijon Charlotte Axén Fereshteh Banihashem Tobias Lilja Petter Tibblin Björn David Persson |
| author_sort | Mikael Leijon |
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| description | During routine sampling of northern pike, a male <i>Esox lucius</i> with circular blue-metallic granular spots mainly located on the head and back was identified. Histological investigations presented multifocally thickened epidermis rich in basophilic large structures with a granulated rim and a dense, non-granulated center. Other organs showed no signs of infection. Ultrastructural analysis of the skin revealed three different types of herpes-like structures predominantly located within enlarged vacuoles. PCR analysis and NGS of dissected skin tissue verified the presence of EsHV1 DNA. In this study, we describe the first identification of EsHV1 in mainland Europe. In addition, for the first time, full sequences of both the DNA polymerase and terminase of the virus is available, thus allowing for an improved phylogenetic placement of EsHV1 within the <i>Alloherpesviridae</i> family. In addition to the EsHV1 infected pike, we also observed that 11.1% of the pike were affected by lymphosarcoma, a hyperplasia-disease caused by retroviruses. In conclusion, viral infections in pike are relatively common and likely have consequences for the local population dynamics. |
| format | Article |
| id | doaj-art-202122c52dc0419eb6c9332b88c71a0f |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-202122c52dc0419eb6c9332b88c71a0f2025-01-24T13:44:42ZengMDPI AGPathogens2076-08172025-01-011414510.3390/pathogens14010045Characterization of Esocid Herpesvirus 1 (EsHV1) from EuropeMikael Leijon0Charlotte Axén1Fereshteh Banihashem2Tobias Lilja3Petter Tibblin4Björn David Persson5Swedish Veterinary Agency, 751 89 Uppsala, SwedenSwedish Veterinary Agency, 751 89 Uppsala, SwedenSwedish Veterinary Agency, 751 89 Uppsala, SwedenSwedish Veterinary Agency, 751 89 Uppsala, SwedenEcology and Evolution in Microbial Model Systems, EEMiS, Department of Biology and Environmental Science, Linnaeus University, 391 82 Kalmar, SwedenSwedish Veterinary Agency, 751 89 Uppsala, SwedenDuring routine sampling of northern pike, a male <i>Esox lucius</i> with circular blue-metallic granular spots mainly located on the head and back was identified. Histological investigations presented multifocally thickened epidermis rich in basophilic large structures with a granulated rim and a dense, non-granulated center. Other organs showed no signs of infection. Ultrastructural analysis of the skin revealed three different types of herpes-like structures predominantly located within enlarged vacuoles. PCR analysis and NGS of dissected skin tissue verified the presence of EsHV1 DNA. In this study, we describe the first identification of EsHV1 in mainland Europe. In addition, for the first time, full sequences of both the DNA polymerase and terminase of the virus is available, thus allowing for an improved phylogenetic placement of EsHV1 within the <i>Alloherpesviridae</i> family. In addition to the EsHV1 infected pike, we also observed that 11.1% of the pike were affected by lymphosarcoma, a hyperplasia-disease caused by retroviruses. In conclusion, viral infections in pike are relatively common and likely have consequences for the local population dynamics.https://www.mdpi.com/2076-0817/14/1/45EsHV1pike<i>Esox lucius</i>northern pikeblue spot diseaseAlloherpesviridae |
| spellingShingle | Mikael Leijon Charlotte Axén Fereshteh Banihashem Tobias Lilja Petter Tibblin Björn David Persson Characterization of Esocid Herpesvirus 1 (EsHV1) from Europe Pathogens EsHV1 pike <i>Esox lucius</i> northern pike blue spot disease Alloherpesviridae |
| title | Characterization of Esocid Herpesvirus 1 (EsHV1) from Europe |
| title_full | Characterization of Esocid Herpesvirus 1 (EsHV1) from Europe |
| title_fullStr | Characterization of Esocid Herpesvirus 1 (EsHV1) from Europe |
| title_full_unstemmed | Characterization of Esocid Herpesvirus 1 (EsHV1) from Europe |
| title_short | Characterization of Esocid Herpesvirus 1 (EsHV1) from Europe |
| title_sort | characterization of esocid herpesvirus 1 eshv1 from europe |
| topic | EsHV1 pike <i>Esox lucius</i> northern pike blue spot disease Alloherpesviridae |
| url | https://www.mdpi.com/2076-0817/14/1/45 |
| work_keys_str_mv | AT mikaelleijon characterizationofesocidherpesvirus1eshv1fromeurope AT charlotteaxen characterizationofesocidherpesvirus1eshv1fromeurope AT fereshtehbanihashem characterizationofesocidherpesvirus1eshv1fromeurope AT tobiaslilja characterizationofesocidherpesvirus1eshv1fromeurope AT pettertibblin characterizationofesocidherpesvirus1eshv1fromeurope AT bjorndavidpersson characterizationofesocidherpesvirus1eshv1fromeurope |