A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary Occlusion
We developed a computational model of the propagation of retinal ischemia in diabetic retinopathy and analyzed the consequences of various patterns and sizes of burns in peripheral retinal photocoagulation. The model addresses retinal ischemia as a phenomenon of adverse local feedback in which once...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2508381 |
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| author | Thomas J. Gast Xiao Fu John Scott Gens James A. Glazier |
| author_facet | Thomas J. Gast Xiao Fu John Scott Gens James A. Glazier |
| author_sort | Thomas J. Gast |
| collection | DOAJ |
| description | We developed a computational model of the propagation of retinal ischemia in diabetic retinopathy and analyzed the consequences of various patterns and sizes of burns in peripheral retinal photocoagulation. The model addresses retinal ischemia as a phenomenon of adverse local feedback in which once a capillary is occluded there is an elevated probability of occlusion of adjacent capillaries resulting in enlarging areas of retinal ischemia as is commonly seen clinically. Retinal burns of different sizes and patterns, treated as local oxygen sources, are predicted to have different effects on the propagation of retinal ischemia. The patterns of retinal burns are optimized with regard to minimization of the sum of the photocoagulated retina and computer predicted ischemic retina. Our simulations show that certain patterns of retinal burns are effective at preventing the spatial spread of ischemia by creating oxygenated boundaries across which the ischemia does not propagate. This model makes no statement about current PRP treatment of avascular peripheral retina and notes that the usual spot sizes used in PRP will not prevent ischemic propagation in still vascularized retinal areas. The model seems to show that a properly patterned laser treatment of still vascularized peripheral retina may be able to prevent or at least constrain the propagation of diabetic retinal ischemia in those retinal areas with intact capillaries. |
| format | Article |
| id | doaj-art-201f937b73dc4423821017618be76f57 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-201f937b73dc4423821017618be76f572025-02-03T01:25:34ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/25083812508381A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary OcclusionThomas J. Gast0Xiao Fu1John Scott Gens2James A. Glazier3School of Optometry, Indiana University, Bloomington, IN 47405, USAThe Biocomplexity Institute, Indiana University, Bloomington, IN 47405, USAThe Biocomplexity Institute, Indiana University, Bloomington, IN 47405, USAThe Biocomplexity Institute, Indiana University, Bloomington, IN 47405, USAWe developed a computational model of the propagation of retinal ischemia in diabetic retinopathy and analyzed the consequences of various patterns and sizes of burns in peripheral retinal photocoagulation. The model addresses retinal ischemia as a phenomenon of adverse local feedback in which once a capillary is occluded there is an elevated probability of occlusion of adjacent capillaries resulting in enlarging areas of retinal ischemia as is commonly seen clinically. Retinal burns of different sizes and patterns, treated as local oxygen sources, are predicted to have different effects on the propagation of retinal ischemia. The patterns of retinal burns are optimized with regard to minimization of the sum of the photocoagulated retina and computer predicted ischemic retina. Our simulations show that certain patterns of retinal burns are effective at preventing the spatial spread of ischemia by creating oxygenated boundaries across which the ischemia does not propagate. This model makes no statement about current PRP treatment of avascular peripheral retina and notes that the usual spot sizes used in PRP will not prevent ischemic propagation in still vascularized retinal areas. The model seems to show that a properly patterned laser treatment of still vascularized peripheral retina may be able to prevent or at least constrain the propagation of diabetic retinal ischemia in those retinal areas with intact capillaries.http://dx.doi.org/10.1155/2016/2508381 |
| spellingShingle | Thomas J. Gast Xiao Fu John Scott Gens James A. Glazier A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary Occlusion Journal of Diabetes Research |
| title | A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary Occlusion |
| title_full | A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary Occlusion |
| title_fullStr | A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary Occlusion |
| title_full_unstemmed | A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary Occlusion |
| title_short | A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary Occlusion |
| title_sort | computational model of peripheral photocoagulation for the prevention of progressive diabetic capillary occlusion |
| url | http://dx.doi.org/10.1155/2016/2508381 |
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