The Effect of St. John’s Wort Oil on Urethral Stricture: An Experimental Study in Rat Model
Objective: The aim was to evaluate the effect of yellow and red centaury St. John’s Wort (St. JW) oil on inflammation and urethral fibrosis development in a rat urethral trauma model. Methods: A total of 24 male rats were divided into 5 groups. No urethral damage was induced in the sham group. Th...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AVES
2024-07-01
|
| Series: | Urology Research and Practice |
| Online Access: | https://urologyresearchandpractice.org/en/the-effect-of-st-john-s-wort-oil-on-urethral-stricture-an-experimental-study-in-rat-model-133950 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832575981119864832 |
|---|---|
| author | Kazım Yelsel Ergün Alma Ömer Yüceer Zeynel Abidin Taş Berna Totan Ateş Murat Kobaner Halil Esimek Adem Altunkol Umut Ünal Ali Ayyıldız |
| author_facet | Kazım Yelsel Ergün Alma Ömer Yüceer Zeynel Abidin Taş Berna Totan Ateş Murat Kobaner Halil Esimek Adem Altunkol Umut Ünal Ali Ayyıldız |
| author_sort | Kazım Yelsel |
| collection | DOAJ |
| description | Objective: The aim was to evaluate the effect of yellow and red centaury St. John’s Wort (St. JW) oil on inflammation and urethral fibrosis development in a rat urethral trauma model.
Methods: A total of 24 male rats were divided into 5 groups. No urethral damage was induced in the sham group. The urethras of all rats in the other groups was traumatized at 6 o’clock with a specially designed urethrotome blade. Group 1 was administered 0.5 cc of St. JW oil once daily for 15 days. Group 2 was administered 0.5 cc of red centaury oil intraurethrally once daily for 15 days. The traumatized rats in Group 3 were not treated (St. JW and red centaury oil were not administered). St. JW oil was administered to 3 rats in the Sham 1 group (Group 4), and red centaury oil was administered to 3 rats in the Sham 2 group (Group 5). A 20-G/32-mm intravenous cannula sheath was used for intraurethral administration. On the 15th day, rats were sacrificed and penectomy was performed for histologic evaluation.
Results: Spongiofibrosis, mucosal inflammation, and congestion were significantly decreased in the yellow St. JW oil group when compared with the red centaury oil group and the untreated group (group to which neither St. JW nor red centaury oil was administered).
Conclusion: In this study, intraurethral administration of yellow St. JW oil was found to significantly reduce mucosal inflammation, spongiofibrosis, and obstruction after urethral trauma. According to the results of this study, we think that St. JW oil may be a promising option in the treatment of urethral stricture. |
| format | Article |
| id | doaj-art-201ae9403b5c4c13a918745e0ba4569d |
| institution | Kabale University |
| issn | 2980-1478 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | AVES |
| record_format | Article |
| series | Urology Research and Practice |
| spelling | doaj-art-201ae9403b5c4c13a918745e0ba4569d2025-01-31T14:43:59ZengAVESUrology Research and Practice2980-14782024-07-0150426126610.5152/tud.2025.24068The Effect of St. John’s Wort Oil on Urethral Stricture: An Experimental Study in Rat ModelKazım Yelsel0https://orcid.org/0000-0002-2642-3699Ergün Alma1https://orcid.org/0000-0003-2633-5274Ömer Yüceer2https://orcid.org/0000-0002-5242-0571Zeynel Abidin Taş3https://orcid.org/0000-0002-5504-4487Berna Totan Ateş4https://orcid.org/0000-0002-9723-1838Murat Kobaner5https://orcid.org/0000-0002-3253-0079Halil Esimek6https://orcid.org/0000-0002-4643-2859Adem Altunkol7https://orcid.org/0000-0002-9300-3694Umut Ünal8https://orcid.org/0000-0003-4040-0044Ali Ayyıldız9https://orcid.org/0000-0003-3334-6051Clinic of Urology, Adana Yüreğir State Hospital, Adana, TürkiyeClinic of Urology, Adana City Training and Research Hospital, Adana, TürkiyeClinic of Emergency Medicine, Niğde Ömer Halisdemir University, Niğde, TürkiyeClinic of Pathology, Adana City Training and Research Hospital, Adana, TürkiyeClinic of Pathology, Adana Yüreğir State Hospital, Adana, TürkiyeClinic of Urology, Adana Yüreğir State Hospital, Adana, TürkiyeErdemli Alata Horticultural Research Institute, Mersin, TürkiyeClinic of Urology, Adana City Training and Research Hospital, Adana, TürkiyeClinic of Urology, Adana City Training and Research Hospital, Adana, TürkiyeDepartment of Urology, Adıyaman University Faculty of Medicine, Adıyaman, TürkiyeObjective: The aim was to evaluate the effect of yellow and red centaury St. John’s Wort (St. JW) oil on inflammation and urethral fibrosis development in a rat urethral trauma model. Methods: A total of 24 male rats were divided into 5 groups. No urethral damage was induced in the sham group. The urethras of all rats in the other groups was traumatized at 6 o’clock with a specially designed urethrotome blade. Group 1 was administered 0.5 cc of St. JW oil once daily for 15 days. Group 2 was administered 0.5 cc of red centaury oil intraurethrally once daily for 15 days. The traumatized rats in Group 3 were not treated (St. JW and red centaury oil were not administered). St. JW oil was administered to 3 rats in the Sham 1 group (Group 4), and red centaury oil was administered to 3 rats in the Sham 2 group (Group 5). A 20-G/32-mm intravenous cannula sheath was used for intraurethral administration. On the 15th day, rats were sacrificed and penectomy was performed for histologic evaluation. Results: Spongiofibrosis, mucosal inflammation, and congestion were significantly decreased in the yellow St. JW oil group when compared with the red centaury oil group and the untreated group (group to which neither St. JW nor red centaury oil was administered). Conclusion: In this study, intraurethral administration of yellow St. JW oil was found to significantly reduce mucosal inflammation, spongiofibrosis, and obstruction after urethral trauma. According to the results of this study, we think that St. JW oil may be a promising option in the treatment of urethral stricture.https://urologyresearchandpractice.org/en/the-effect-of-st-john-s-wort-oil-on-urethral-stricture-an-experimental-study-in-rat-model-133950 |
| spellingShingle | Kazım Yelsel Ergün Alma Ömer Yüceer Zeynel Abidin Taş Berna Totan Ateş Murat Kobaner Halil Esimek Adem Altunkol Umut Ünal Ali Ayyıldız The Effect of St. John’s Wort Oil on Urethral Stricture: An Experimental Study in Rat Model Urology Research and Practice |
| title | The Effect of St. John’s Wort Oil on Urethral Stricture: An Experimental Study in Rat Model |
| title_full | The Effect of St. John’s Wort Oil on Urethral Stricture: An Experimental Study in Rat Model |
| title_fullStr | The Effect of St. John’s Wort Oil on Urethral Stricture: An Experimental Study in Rat Model |
| title_full_unstemmed | The Effect of St. John’s Wort Oil on Urethral Stricture: An Experimental Study in Rat Model |
| title_short | The Effect of St. John’s Wort Oil on Urethral Stricture: An Experimental Study in Rat Model |
| title_sort | effect of st john s wort oil on urethral stricture an experimental study in rat model |
| url | https://urologyresearchandpractice.org/en/the-effect-of-st-john-s-wort-oil-on-urethral-stricture-an-experimental-study-in-rat-model-133950 |
| work_keys_str_mv | AT kazımyelsel theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT ergunalma theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT omeryuceer theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT zeynelabidintas theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT bernatotanates theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT muratkobaner theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT halilesimek theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT ademaltunkol theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT umutunal theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT aliayyıldız theeffectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT kazımyelsel effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT ergunalma effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT omeryuceer effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT zeynelabidintas effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT bernatotanates effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT muratkobaner effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT halilesimek effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT ademaltunkol effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT umutunal effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel AT aliayyıldız effectofstjohnswortoilonurethralstrictureanexperimentalstudyinratmodel |