Antimicrobial activity of Ricinus comunis, Swietenia mahogani and Crusentia cujete ethanol extracts against multidrug resistant pathogens, recovered from a hospital environment
Medicinal plants have been used as effective approaches to manage multidrug resistant pathogens, including infectious agents that cause nosocomial infections. This study aimed to investigate the antimicrobial potentials of ethanolic extracts of Ricinus comunis, Swietenia mahogani and Crusentia cuj...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ResearchersLinks, Ltd
2021-02-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://nrmj.journals.ekb.eg/article_149388_b66e8ad4ef31321b423ccf1cacab7eae.pdf |
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| Summary: | Medicinal plants have been used as effective approaches to manage multidrug resistant pathogens, including
infectious agents that cause nosocomial infections. This study aimed to investigate the antimicrobial potentials of
ethanolic extracts of Ricinus comunis, Swietenia mahogani and Crusentia cujete against five multidrug resistant
nosocomial pathogens namely; Staphylococcus aureus, Pseudomonas sp., Klebsiella sp., Escherichia coli and
Candida sp., which were isolated from hospital fomites. Using standard microbiological methods, fomite swab
samples from ward beddings and door handles from the casualty, women, and children ward of Dalhatu-Araf
Specialist Hospital, Lafia, Nigeria, were assessed. A total of 251 microbial isolates, consisting of 8 bacterial and 6
fungal genera were recovered. The highest frequency of microbial pathogens was recorded in the casualty unit
(98[39%]), followed by the women’s unit (90[36%]), while the children’s ward (63[25%]) was the least
contaminated. S. aureus (25[42%]) and Aspergillus sp. (43[72%]) were the most isolated bacteria and fungi;
respectively, while Salmonella sp. (7[12%]) and Trichoderma sp. (9[15%]) were the least isolated. However,
there were no significantly statistical differences across wards and microbial isolates. The five selected isolates
were tested for in vitro susceptibility against several standard antibiotics to check their multiple drug resistance.
The tested microorganisms exhibited various levels of multidrug resistance patterns except for Candida sp. which
was resistant to two classes of antibiotics (azole group and griseofulvin). On the other hand, Klebsiella sp. was
resistant to eight antibiotics of four classes. The ethanolic leaf extract of C. cujete was more effective against all
the selected microbial pathogens, while the bark extract of S. mahogani was substantially effective. R. comunis
exhibited no inhibitory potential against any of the tested pathogens. All the plant extracts were not as effective
against the tested microorganisms as the conventional antibiotics that were used as positive controls. Results
obtained indicate the risk of nosocomial infections caused by multidrug resistant pathogens originating from the
hospital environment. Good hygienic practices, public awareness on nosocomial infections and further research
into ethnomedicine are hereby recommended |
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| ISSN: | 2537-0286 2537-0294 |