DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage

DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage

BackgroundCantharidin (CTD) extracted from the traditional Chinese medicine Mylabris has significant therapeutic effects on various tumors. However, the high toxicity of CTD can cause serious liver damage, although the related molecular mechanisms remain unclear.MethodsIn this study, we established...

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Bibliographic Details
Main Authors: Wenchao Tang, Yue Pan, Can Zhu, Didong Lou, Fang Peng, Qin Shi, Yuanyuan Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
cantharidin
liver injury
DDIT4
mTOR signaling pathway
autophagy
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1480512/full
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