Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota
Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed betw...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/4230590 |
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| author | Yiqiang Xie Man Xiao Yali Ni Shangfei Jiang Guizhu Feng Shenggang Sang Guankui Du |
| author_facet | Yiqiang Xie Man Xiao Yali Ni Shangfei Jiang Guizhu Feng Shenggang Sang Guankui Du |
| author_sort | Yiqiang Xie |
| collection | DOAJ |
| description | Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed between db-/db- mice and normal mice (DB/DB) and between the db-/db mice treated and untreated with AOE using next-generation sequencing technology. Our results showed that the db-/db-AOE group had improved glycemic control and renal function compared with the db-/db-H2O group. Compared with the db-/db-H2O group, AOE administration resulted in significantly increased ratio of Bacteroidetes-to-Firmicutes in db-/db- mice. In addition, the abundance of Akkermansia was significantly increased, while Helicobacter was significantly suppressed in the db-/db-AOE group compared with the db-/db-H2O group. Our data suggest that AOE treatment decreased blood glucose levels and significantly reduced damage of renal pathology in the T2DM mice by modulating gut microbiota composition. |
| format | Article |
| id | doaj-art-1ff03ae448a44b79a09778679b7455fa |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1ff03ae448a44b79a09778679b7455fa2025-02-03T01:00:21ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/42305904230590Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut MicrobiotaYiqiang Xie0Man Xiao1Yali Ni2Shangfei Jiang3Guizhu Feng4Shenggang Sang5Guankui Du6First Affiliated Hospital of Hainan Medical University, Haikou 571199, ChinaDepartment of Biochemistry and Molecular Biology, Hainan Medical University, Haikou 571101, ChinaFirst Affiliated Hospital of Hainan Medical University, Haikou 571199, ChinaDepartment of Biochemistry and Molecular Biology, Hainan Medical University, Haikou 571101, ChinaDepartment of Biochemistry and Molecular Biology, Hainan Medical University, Haikou 571101, ChinaFirst Affiliated Hospital of Hainan Medical University, Haikou 571199, ChinaDepartment of Biochemistry and Molecular Biology, Hainan Medical University, Haikou 571101, ChinaRecently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. We performed an 8-week administration protocol on T2DM (C57BL/6J db-/db-) mice and fecal samples were collected. Comparisons of fecal bacterial communities were performed between db-/db- mice and normal mice (DB/DB) and between the db-/db mice treated and untreated with AOE using next-generation sequencing technology. Our results showed that the db-/db-AOE group had improved glycemic control and renal function compared with the db-/db-H2O group. Compared with the db-/db-H2O group, AOE administration resulted in significantly increased ratio of Bacteroidetes-to-Firmicutes in db-/db- mice. In addition, the abundance of Akkermansia was significantly increased, while Helicobacter was significantly suppressed in the db-/db-AOE group compared with the db-/db-H2O group. Our data suggest that AOE treatment decreased blood glucose levels and significantly reduced damage of renal pathology in the T2DM mice by modulating gut microbiota composition.http://dx.doi.org/10.1155/2018/4230590 |
| spellingShingle | Yiqiang Xie Man Xiao Yali Ni Shangfei Jiang Guizhu Feng Shenggang Sang Guankui Du Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota Journal of Diabetes Research |
| title | Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota |
| title_full | Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota |
| title_fullStr | Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota |
| title_full_unstemmed | Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota |
| title_short | Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota |
| title_sort | alpinia oxyphylla miq extract prevents diabetes in mice by modulating gut microbiota |
| url | http://dx.doi.org/10.1155/2018/4230590 |
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