Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft
The incidence of renal cell carcinoma (RCC) in renal allograft in transplant recipients is 0.22–0.25%. De novo clear cell, papillary, and chromophobe RCCs and RCCs with sarcomatoid differentiation originating in renal allograft have been reported. Routine surveillance for graft tumours is not routin...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2017/4232474 |
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| author | Abdullah Alharbi Maram S. Al Turki Noura Aloudah Khaled O. Alsaad |
| author_facet | Abdullah Alharbi Maram S. Al Turki Noura Aloudah Khaled O. Alsaad |
| author_sort | Abdullah Alharbi |
| collection | DOAJ |
| description | The incidence of renal cell carcinoma (RCC) in renal allograft in transplant recipients is 0.22–0.25%. De novo clear cell, papillary, and chromophobe RCCs and RCCs with sarcomatoid differentiation originating in renal allograft have been reported. Routine surveillance for graft tumours is not routinely practiced and these tumours are commonly asymptomatic and incidentally discovered. We describe a case of incidental, eosinophilic chromophobe RCC in a 31-year-old, long-term renal transplant male recipient, who presented with acute gastroenteritis 11 years after transplantation. The graft was nonfunctional at the time of presentation. Abdominal ultrasound and computed tomography scan demonstrated 1.8 cm well-defined, round enhancing lesion, confined to the renal allograft and suspicious for malignancy. Pathological examination of graft nephrectomy specimen showed gross, histopathological, and immunohistochemical features of eosinophilic chromophobe RCC. Fifty-five months after surgery, the patient was alive and free of malignancy. To the best of our knowledge, only five chromophobe RCCs originating in a renal allograft were previously described in English literature. We suggest that chromophobe RCC should be considered in the differential diagnosis of renal allograft mass, including eosinophilic tumours, and emphasise the importance of periodic screening of renal allograft in all renal transplant recipients. |
| format | Article |
| id | doaj-art-1fe936a6dacb4ab595973d1d051d122e |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-1fe936a6dacb4ab595973d1d051d122e2025-02-03T06:44:28ZengWileyCase Reports in Transplantation2090-69432090-69512017-01-01201710.1155/2017/42324744232474Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal AllograftAbdullah Alharbi0Maram S. Al Turki1Noura Aloudah2Khaled O. Alsaad3Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi ArabiaDepartment of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi ArabiaDepartment of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi ArabiaThe incidence of renal cell carcinoma (RCC) in renal allograft in transplant recipients is 0.22–0.25%. De novo clear cell, papillary, and chromophobe RCCs and RCCs with sarcomatoid differentiation originating in renal allograft have been reported. Routine surveillance for graft tumours is not routinely practiced and these tumours are commonly asymptomatic and incidentally discovered. We describe a case of incidental, eosinophilic chromophobe RCC in a 31-year-old, long-term renal transplant male recipient, who presented with acute gastroenteritis 11 years after transplantation. The graft was nonfunctional at the time of presentation. Abdominal ultrasound and computed tomography scan demonstrated 1.8 cm well-defined, round enhancing lesion, confined to the renal allograft and suspicious for malignancy. Pathological examination of graft nephrectomy specimen showed gross, histopathological, and immunohistochemical features of eosinophilic chromophobe RCC. Fifty-five months after surgery, the patient was alive and free of malignancy. To the best of our knowledge, only five chromophobe RCCs originating in a renal allograft were previously described in English literature. We suggest that chromophobe RCC should be considered in the differential diagnosis of renal allograft mass, including eosinophilic tumours, and emphasise the importance of periodic screening of renal allograft in all renal transplant recipients.http://dx.doi.org/10.1155/2017/4232474 |
| spellingShingle | Abdullah Alharbi Maram S. Al Turki Noura Aloudah Khaled O. Alsaad Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft Case Reports in Transplantation |
| title | Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft |
| title_full | Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft |
| title_fullStr | Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft |
| title_full_unstemmed | Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft |
| title_short | Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft |
| title_sort | incidental eosinophilic chromophobe renal cell carcinoma in renal allograft |
| url | http://dx.doi.org/10.1155/2017/4232474 |
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