E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma
Background: Oral squamous cell carcinoma is a common cancer of head and neck region with poor prognosis and may sometimes show a premalignant stage. Cell-cell adhesion molecules play an important role in the process of malignant transformation. E-cadherin, a cell-to-cell adhesion molecule, plays a c...
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Elsevier
2025-05-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426825000569 |
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| author | Dhanusree Kani Vindhya Savithri Rakesh Suresh Ramanarayanan Venkitachalam Mahija Janardhanan Thara Aravind |
| author_facet | Dhanusree Kani Vindhya Savithri Rakesh Suresh Ramanarayanan Venkitachalam Mahija Janardhanan Thara Aravind |
| author_sort | Dhanusree Kani |
| collection | DOAJ |
| description | Background: Oral squamous cell carcinoma is a common cancer of head and neck region with poor prognosis and may sometimes show a premalignant stage. Cell-cell adhesion molecules play an important role in the process of malignant transformation. E-cadherin, a cell-to-cell adhesion molecule, plays a crucial role in maintaining cell polarity and adhesion of epithelial cells. Aims: To assess the expression of E-cadherin in various grades of oral epithelial dysplasia and oral squamous cells carcinoma and compare it to unremarkable oral mucosa. Materials and methods: The study comprised a total sample size of 80 with 10 cases of unremarkable oral mucosa which is the control group, 40 cases of oral epithelial dysplasia and 30 cases of oral squamous cell carcinoma. One section was stained with haematoxylin and eosin to confirm the histopathological diagnosis and other section was stained immunohistochemically with E-cadherin. Results: The study found that E-cadherin expression was strongly positive in unremarkable mucosal epithelium, reduced in oral epithelial dysplasia, and gradually decreased as it progressed to oral squamous cell carcinoma. These findings were found to be statistically significant. Conclusion: The study found a correlation between E-cadherin expression loss and oral squamous cell carcinoma progression, suggesting that E-cadherin can serve as a diagnostic biomarker for malignant transformation of oral epithelial dysplasia and predict disease prognosis in oral squamous cell carcinoma. |
| format | Article |
| id | doaj-art-1fde3e19e4b2432a87d7dd777c1ba2e2 |
| institution | OA Journals |
| issn | 2212-4268 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-1fde3e19e4b2432a87d7dd777c1ba2e22025-08-20T01:49:23ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-05-0115350851410.1016/j.jobcr.2025.02.015E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinomaDhanusree Kani0Vindhya Savithri1Rakesh Suresh2Ramanarayanan Venkitachalam3Mahija Janardhanan4Thara Aravind5Department of Oral & Maxillofacial Pathology and Microbiology, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, AIMS Ponekkara PO, Kochi, Kerala, 682041, IndiaDepartment of Oral & Maxillofacial Pathology and Microbiology, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, AIMS Ponekkara PO, Kochi, Kerala, 682041, India; Corresponding author. Department of Oral & Maxillofacial Pathology & Microbiology, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, AIMS Campus, Kochi, Kerala, 682041, India.Department of Oral & Maxillofacial Pathology and Microbiology, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, AIMS Ponekkara PO, Kochi, Kerala, 682041, IndiaDepartment of Public Health Dentistry, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, AIMS Ponekkara PO, Kochi, Kerala, 682041, IndiaDepartment of Oral & Maxillofacial Pathology and Microbiology, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, AIMS Ponekkara PO, Kochi, Kerala, 682041, IndiaDepartment of Oral & Maxillofacial Pathology and Microbiology, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, AIMS Ponekkara PO, Kochi, Kerala, 682041, IndiaBackground: Oral squamous cell carcinoma is a common cancer of head and neck region with poor prognosis and may sometimes show a premalignant stage. Cell-cell adhesion molecules play an important role in the process of malignant transformation. E-cadherin, a cell-to-cell adhesion molecule, plays a crucial role in maintaining cell polarity and adhesion of epithelial cells. Aims: To assess the expression of E-cadherin in various grades of oral epithelial dysplasia and oral squamous cells carcinoma and compare it to unremarkable oral mucosa. Materials and methods: The study comprised a total sample size of 80 with 10 cases of unremarkable oral mucosa which is the control group, 40 cases of oral epithelial dysplasia and 30 cases of oral squamous cell carcinoma. One section was stained with haematoxylin and eosin to confirm the histopathological diagnosis and other section was stained immunohistochemically with E-cadherin. Results: The study found that E-cadherin expression was strongly positive in unremarkable mucosal epithelium, reduced in oral epithelial dysplasia, and gradually decreased as it progressed to oral squamous cell carcinoma. These findings were found to be statistically significant. Conclusion: The study found a correlation between E-cadherin expression loss and oral squamous cell carcinoma progression, suggesting that E-cadherin can serve as a diagnostic biomarker for malignant transformation of oral epithelial dysplasia and predict disease prognosis in oral squamous cell carcinoma.http://www.sciencedirect.com/science/article/pii/S2212426825000569E-cadherinEpithelial mesenchymal interactionCell-cell adhesionOral epithelial dysplasiaOral squamous cell carcinoma |
| spellingShingle | Dhanusree Kani Vindhya Savithri Rakesh Suresh Ramanarayanan Venkitachalam Mahija Janardhanan Thara Aravind E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma Journal of Oral Biology and Craniofacial Research E-cadherin Epithelial mesenchymal interaction Cell-cell adhesion Oral epithelial dysplasia Oral squamous cell carcinoma |
| title | E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma |
| title_full | E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma |
| title_fullStr | E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma |
| title_full_unstemmed | E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma |
| title_short | E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma |
| title_sort | e cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma |
| topic | E-cadherin Epithelial mesenchymal interaction Cell-cell adhesion Oral epithelial dysplasia Oral squamous cell carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2212426825000569 |
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