Advances in Illuminating Prostate Cancer with Emerging Phototherapies
Prostate cancer is a worldwide health concern in men, with substantially high incidence rate and advanced metastatic disease-related mortality rates. Despite advancements in diagnostics and treatment options, conventional therapies for prostate cancer, including surgery, radiotherapy, chemotherapy a...
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Asian Medical Press Ltd.(H.K.)
2025-01-01
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| Series: | Annals of Urologic Oncology |
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| Online Access: | http://auo.asmepress.com/articles/new-43-655.html |
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| author | Ali Usman |
| author_facet | Ali Usman |
| author_sort | Ali Usman |
| collection | DOAJ |
| description | Prostate cancer is a worldwide health concern in men, with substantially high incidence rate and advanced metastatic disease-related mortality rates. Despite advancements in diagnostics and treatment options, conventional therapies for prostate cancer, including surgery, radiotherapy, chemotherapy and androgen deprivation therapy, face limitations such as treatment resistance, limited precision and off-target side-effects. Hence, identification and clinical translation of novel therapeutic strategies is urgently needed. In this regard, phototherapies, such as photodynamic therapy (PDT) and photothermal therapy (PTT), are emerging as promising options for addressing the challenges associated with conventional treatment options. Utilizing near-infrared (NIR) light to selectively target cancer cells, these approaches spare healthy tissues. PDT employs photosensitizers to produce reactive oxygen species, thereby stimulating anti-tumor immune responses, disrupting the tumor microvasculature and/or inducing aopotitic or necrotic cell death. In contrast, PTT leverages photothermal agents to generate localized hyperthermia, achieving effective thermal ablation of tumor cells. Recent advancements in nanoparticle technology have significantly improved the efficacy and specificity of these phototherapies. Functionalized nanoparticles, such as those targeting prostate-specific membrane antigen (PSMA), enhance the precision of therapeutic delivery, reducing systemic toxicity. Combination strategies incorporating PDT and PTT with conventional modalities, including surgery, chemotherapy and immunotherapy, have demonstrated synergistic effects, leading to better therapy sensitization. Preclinical and clinical studies underline the potential of these multimodal approaches to enhance treatment outcomes, particularly for advanced and castration-resistant prostate cancer. This review explores the recent innovations in illuminating prostate cancer with phototherapies, their combination with conventional therapies, and their clinical potential in reducing the global prostate cancer burden. |
| format | Article |
| id | doaj-art-1fd02d2e8d1e42a4855760ad811dbd87 |
| institution | Kabale University |
| issn | 2617-7765 2617-7773 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Asian Medical Press Ltd.(H.K.) |
| record_format | Article |
| series | Annals of Urologic Oncology |
| spelling | doaj-art-1fd02d2e8d1e42a4855760ad811dbd872025-01-31T07:37:28ZengAsian Medical Press Ltd.(H.K.)Annals of Urologic Oncology2617-77652617-77732025-01-0110.32948/auo.2025.01.29Advances in Illuminating Prostate Cancer with Emerging PhototherapiesAli Usman0Department of Pharmacology, Boston University, Boston, MA 02215, USA.Prostate cancer is a worldwide health concern in men, with substantially high incidence rate and advanced metastatic disease-related mortality rates. Despite advancements in diagnostics and treatment options, conventional therapies for prostate cancer, including surgery, radiotherapy, chemotherapy and androgen deprivation therapy, face limitations such as treatment resistance, limited precision and off-target side-effects. Hence, identification and clinical translation of novel therapeutic strategies is urgently needed. In this regard, phototherapies, such as photodynamic therapy (PDT) and photothermal therapy (PTT), are emerging as promising options for addressing the challenges associated with conventional treatment options. Utilizing near-infrared (NIR) light to selectively target cancer cells, these approaches spare healthy tissues. PDT employs photosensitizers to produce reactive oxygen species, thereby stimulating anti-tumor immune responses, disrupting the tumor microvasculature and/or inducing aopotitic or necrotic cell death. In contrast, PTT leverages photothermal agents to generate localized hyperthermia, achieving effective thermal ablation of tumor cells. Recent advancements in nanoparticle technology have significantly improved the efficacy and specificity of these phototherapies. Functionalized nanoparticles, such as those targeting prostate-specific membrane antigen (PSMA), enhance the precision of therapeutic delivery, reducing systemic toxicity. Combination strategies incorporating PDT and PTT with conventional modalities, including surgery, chemotherapy and immunotherapy, have demonstrated synergistic effects, leading to better therapy sensitization. Preclinical and clinical studies underline the potential of these multimodal approaches to enhance treatment outcomes, particularly for advanced and castration-resistant prostate cancer. This review explores the recent innovations in illuminating prostate cancer with phototherapies, their combination with conventional therapies, and their clinical potential in reducing the global prostate cancer burden.http://auo.asmepress.com/articles/new-43-655.htmlprostate cancerphotodynamic therapyphotothermal therapytargeted therapycombination therapy |
| spellingShingle | Ali Usman Advances in Illuminating Prostate Cancer with Emerging Phototherapies Annals of Urologic Oncology prostate cancer photodynamic therapy photothermal therapy targeted therapy combination therapy |
| title | Advances in Illuminating Prostate Cancer with Emerging Phototherapies |
| title_full | Advances in Illuminating Prostate Cancer with Emerging Phototherapies |
| title_fullStr | Advances in Illuminating Prostate Cancer with Emerging Phototherapies |
| title_full_unstemmed | Advances in Illuminating Prostate Cancer with Emerging Phototherapies |
| title_short | Advances in Illuminating Prostate Cancer with Emerging Phototherapies |
| title_sort | advances in illuminating prostate cancer with emerging phototherapies |
| topic | prostate cancer photodynamic therapy photothermal therapy targeted therapy combination therapy |
| url | http://auo.asmepress.com/articles/new-43-655.html |
| work_keys_str_mv | AT aliusman advancesinilluminatingprostatecancerwithemergingphototherapies |