Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer
Abstract Background Colorectal cancer (CRC) is one common tumor with the high death rate, and badly affects the normal lives of CRC patients. Amarogentin (AG) has been found to exhibit regulatory roles and join into the progression of multiple diseases. However, the regulatory impacts and associated...
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BMC
2025-01-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03649-w |
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| author | Chao Wang Zihao You Guoqing Zhou Juanjuan Dong Sihao Tong Guoping Sun |
| author_facet | Chao Wang Zihao You Guoqing Zhou Juanjuan Dong Sihao Tong Guoping Sun |
| author_sort | Chao Wang |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC) is one common tumor with the high death rate, and badly affects the normal lives of CRC patients. Amarogentin (AG) has been found to exhibit regulatory roles and join into the progression of multiple diseases. However, the regulatory impacts and associated molecular mechanisms of AG in CRC progression keep unclear. Methods and results In this study, it was demonstrated that AG weakened CRC cell viability in a concentration- and time-dependent manner. In addition, AG accelerated cell apoptosis by triggering ferroptosis. The cell invasion and EMT process were restrained after AG treatment, but these impacts were reversed after Fer-1 addition. Moreover, it was uncovered that AG retarded Nrf2/HO-1/GPX4 activation. Additionally, AG modulated PTC cell viability and stimulated ferroptosis. At last, it was illustrated that AG suppressed tumor growth in vivo. Conclusion In conclusion, it was disclosed that AG suppressed cell proliferation and EMT process through inducing ferroptosis in CRC, and retarded Nrf2/HO-1/GPX4 activation. This discovery suggested that AG may be one effective drug for ameliorating CRC progression. |
| format | Article |
| id | doaj-art-1faa8ffce7e8400ba06ebaa43731fd1f |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-1faa8ffce7e8400ba06ebaa43731fd1f2025-02-02T12:27:16ZengBMCBMC Gastroenterology1471-230X2025-01-012511910.1186/s12876-025-03649-wAmarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancerChao Wang0Zihao You1Guoqing Zhou2Juanjuan Dong3Sihao Tong4Guoping Sun5Department of Oncology, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Oncology, Chaohu Hospital of Anhui Medical UniversityDepartment of Oncology, Chaohu Hospital of Anhui Medical UniversityDepartment of Oncology, Chaohu Hospital of Anhui Medical UniversityDepartment of Oncology, Chaohu Hospital of Anhui Medical UniversityDepartment of Oncology, The First Affiliated Hospital of Anhui Medical UniversityAbstract Background Colorectal cancer (CRC) is one common tumor with the high death rate, and badly affects the normal lives of CRC patients. Amarogentin (AG) has been found to exhibit regulatory roles and join into the progression of multiple diseases. However, the regulatory impacts and associated molecular mechanisms of AG in CRC progression keep unclear. Methods and results In this study, it was demonstrated that AG weakened CRC cell viability in a concentration- and time-dependent manner. In addition, AG accelerated cell apoptosis by triggering ferroptosis. The cell invasion and EMT process were restrained after AG treatment, but these impacts were reversed after Fer-1 addition. Moreover, it was uncovered that AG retarded Nrf2/HO-1/GPX4 activation. Additionally, AG modulated PTC cell viability and stimulated ferroptosis. At last, it was illustrated that AG suppressed tumor growth in vivo. Conclusion In conclusion, it was disclosed that AG suppressed cell proliferation and EMT process through inducing ferroptosis in CRC, and retarded Nrf2/HO-1/GPX4 activation. This discovery suggested that AG may be one effective drug for ameliorating CRC progression.https://doi.org/10.1186/s12876-025-03649-wAmarogentinEMT processFerroptosisColorectal cancerNrf2/HO-1/GPX |
| spellingShingle | Chao Wang Zihao You Guoqing Zhou Juanjuan Dong Sihao Tong Guoping Sun Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer BMC Gastroenterology Amarogentin EMT process Ferroptosis Colorectal cancer Nrf2/HO-1/GPX |
| title | Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer |
| title_full | Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer |
| title_fullStr | Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer |
| title_full_unstemmed | Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer |
| title_short | Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer |
| title_sort | amarogentin suppresses cell proliferation and emt process through inducing ferroptosis in colorectal cancer |
| topic | Amarogentin EMT process Ferroptosis Colorectal cancer Nrf2/HO-1/GPX |
| url | https://doi.org/10.1186/s12876-025-03649-w |
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