LPS2336, a New TREK-1 Channel Activator Identified by High Throughput Screening

LPS2336, a New TREK-1 Channel Activator Identified by High Throughput Screening

TWIK-related K+ (TREK-1) channels are involved in pain perception and their pharmacological activation has potential for pain relief. The development of new pharmacological tools to study these channels and enrich our knowledge of structure–activity relationships is therefore important. We optimized...

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Bibliographic Details
Main Authors: Romane Boyer, Romane Bony, Maxence Maugis, Julien Schopp, Marion Leroux, Clément Michelin, Laurie Gonthier, Quentin Grzeskiewicz, Alexandre Jouannet, Youssef Aissouni, Bruno Didier, Mihaela Gulea, Nicolas Girard, Jean-Christophe Cintrat, Antoine Dumeige, Jérôme Busserolles, Sylvie Ducki, Stéphane Lolignier
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
TREK-1
high throughput screening
structure–activity relationship
pain
analgesia
Online Access:https://www.mdpi.com/2218-273X/15/5/740
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