Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma
The transformation of a benign hemangioma into a malignant angiosarcoma has been rarely reported, with only 11 cases reported in the literature. There have been no reports of malignant transformation of hemangioma into angiosarcoma in association with epithelioid hemangioendothelioma, to our knowled...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/185323 |
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| author | Michael J. Nathenson Diana Molavi Albert Aboulafia |
| author_facet | Michael J. Nathenson Diana Molavi Albert Aboulafia |
| author_sort | Michael J. Nathenson |
| collection | DOAJ |
| description | The transformation of a benign hemangioma into a malignant angiosarcoma has been rarely reported, with only 11 cases reported in the literature. There have been no reports of malignant transformation of hemangioma into angiosarcoma in association with epithelioid hemangioendothelioma, to our knowledge. The existence of precursor malignancies in the tumorigenesis of sarcomas is still not clearly defined. We describe the case of a 40-year-old woman with a preceding history of a suspected hemangioma for ten years, who upon resection was found on histology to have evidence of a hemangioma with an associated area of epithelioid hemangioendothelioma as well as areas of overt high grade epithelioid angiosarcoma. These findings raise the possibility of the evolution of hemangioma to epithelioid hemangioendothelioma, and the latter to overt angiosarcoma. The patient was managed as having a high grade sarcoma with wide resection and radiation. She declined systemic adjuvant chemotherapy after a thorough discussion about the risks and benefits of chemotherapy, and she currently remains disease free one year after the surgery. |
| format | Article |
| id | doaj-art-1fa1baca1a664829a7a822fb461e0549 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-1fa1baca1a664829a7a822fb461e05492025-02-03T05:49:44ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/185323185323Angiosarcoma Arising in a Patient with a 10-Year-Old HemangiomaMichael J. Nathenson0Diana Molavi1Albert Aboulafia2University of Maryland Greenebaum Cancer Center, 22 South Greene Street, Suite 9D10, Baltimore, MD 21201, USADepartment of Pathology, Sinai Hospital, 2401 W. Belvedere Avenue, Baltimore, MD 21215, USASarcoma Services, Cancer Institute Sinai Hospital, 2401 W. Belvedere Avenue, Baltimore, MD 21215, USAThe transformation of a benign hemangioma into a malignant angiosarcoma has been rarely reported, with only 11 cases reported in the literature. There have been no reports of malignant transformation of hemangioma into angiosarcoma in association with epithelioid hemangioendothelioma, to our knowledge. The existence of precursor malignancies in the tumorigenesis of sarcomas is still not clearly defined. We describe the case of a 40-year-old woman with a preceding history of a suspected hemangioma for ten years, who upon resection was found on histology to have evidence of a hemangioma with an associated area of epithelioid hemangioendothelioma as well as areas of overt high grade epithelioid angiosarcoma. These findings raise the possibility of the evolution of hemangioma to epithelioid hemangioendothelioma, and the latter to overt angiosarcoma. The patient was managed as having a high grade sarcoma with wide resection and radiation. She declined systemic adjuvant chemotherapy after a thorough discussion about the risks and benefits of chemotherapy, and she currently remains disease free one year after the surgery.http://dx.doi.org/10.1155/2014/185323 |
| spellingShingle | Michael J. Nathenson Diana Molavi Albert Aboulafia Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma Case Reports in Oncological Medicine |
| title | Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma |
| title_full | Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma |
| title_fullStr | Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma |
| title_full_unstemmed | Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma |
| title_short | Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma |
| title_sort | angiosarcoma arising in a patient with a 10 year old hemangioma |
| url | http://dx.doi.org/10.1155/2014/185323 |
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