Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children
Recurrent respiratory tract infections (RRTIs) are a common condition in pediatrics and significantly impact children's quality of life; however, their pathogenesis and contributing factors are not yet fully elucidated. Probiotics have recently emerged as promising agents for modulating intesti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1508613/full |
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| author | Yali Zhang Yali Zhang Yingying Xu Yingying Xu Ling Hu Ling Hu Xiaomei Wang |
| author_facet | Yali Zhang Yali Zhang Yingying Xu Yingying Xu Ling Hu Ling Hu Xiaomei Wang |
| author_sort | Yali Zhang |
| collection | DOAJ |
| description | Recurrent respiratory tract infections (RRTIs) are a common condition in pediatrics and significantly impact children's quality of life; however, their pathogenesis and contributing factors are not yet fully elucidated. Probiotics have recently emerged as promising agents for modulating intestinal microecology and have gained considerable attention in clinical research on preventing and treating RRTIs in children. This article provides an initial overview of the concept, classification, and mechanisms underlying probiotics. It emphasizes their beneficial effects on respiratory health by modulating intestinal microbial equilibrium, augmenting immune system functionality, and attenuating inflammatory responses. Subsequently, we examine existing research regarding the use of probiotics in pediatric RRTIs. Numerous clinical trials have unequivocally demonstrated that supplementing with probiotics can significantly reduce both the frequency and severity of RRTIs in children while also simultaneously decreasing antibiotic usage. However, there are ongoing controversies and challenges in current research concerning the influence of probiotic type, dosage, duration of use, and other factors on efficacy. Furthermore, variations have been observed across different studies. Additionally, it is crucial to further evaluate the safety and potential long-term side effects associated with probiotic use in children with RRTIs. In conclusion, we propose future research directions including conducting more high-quality randomized controlled trials to optimize application strategies for probiotics alongside other treatments while considering variations based on age and health conditions among pediatric populations. Finally, in summary although probiotics exhibit promising benefits in preventing and treating RRTIs in children; additional studies are necessary to refine their application strategies ensuring both safety and effectiveness. |
| format | Article |
| id | doaj-art-1fa0763bd5ef4d14855a8485b0e66906 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-1fa0763bd5ef4d14855a8485b0e669062025-02-06T07:09:22ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-02-011310.3389/fped.2025.15086131508613Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in childrenYali Zhang0Yali Zhang1Yingying Xu2Yingying Xu3Ling Hu4Ling Hu5Xiaomei Wang6Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, ChinaHubei Province Key Laboratory of Occupational Hazard Identification and Control, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaTianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, ChinaHubei Province Key Laboratory of Occupational Hazard Identification and Control, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaTianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, ChinaHubei Province Key Laboratory of Occupational Hazard Identification and Control, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaHubei Province Key Laboratory of Occupational Hazard Identification and Control, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, ChinaRecurrent respiratory tract infections (RRTIs) are a common condition in pediatrics and significantly impact children's quality of life; however, their pathogenesis and contributing factors are not yet fully elucidated. Probiotics have recently emerged as promising agents for modulating intestinal microecology and have gained considerable attention in clinical research on preventing and treating RRTIs in children. This article provides an initial overview of the concept, classification, and mechanisms underlying probiotics. It emphasizes their beneficial effects on respiratory health by modulating intestinal microbial equilibrium, augmenting immune system functionality, and attenuating inflammatory responses. Subsequently, we examine existing research regarding the use of probiotics in pediatric RRTIs. Numerous clinical trials have unequivocally demonstrated that supplementing with probiotics can significantly reduce both the frequency and severity of RRTIs in children while also simultaneously decreasing antibiotic usage. However, there are ongoing controversies and challenges in current research concerning the influence of probiotic type, dosage, duration of use, and other factors on efficacy. Furthermore, variations have been observed across different studies. Additionally, it is crucial to further evaluate the safety and potential long-term side effects associated with probiotic use in children with RRTIs. In conclusion, we propose future research directions including conducting more high-quality randomized controlled trials to optimize application strategies for probiotics alongside other treatments while considering variations based on age and health conditions among pediatric populations. Finally, in summary although probiotics exhibit promising benefits in preventing and treating RRTIs in children; additional studies are necessary to refine their application strategies ensuring both safety and effectiveness.https://www.frontiersin.org/articles/10.3389/fped.2025.1508613/fullrecurrent respiratory tract infectionsprobioticschildrenpreventionhealth |
| spellingShingle | Yali Zhang Yali Zhang Yingying Xu Yingying Xu Ling Hu Ling Hu Xiaomei Wang Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children Frontiers in Pediatrics recurrent respiratory tract infections probiotics children prevention health |
| title | Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children |
| title_full | Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children |
| title_fullStr | Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children |
| title_full_unstemmed | Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children |
| title_short | Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children |
| title_sort | advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children |
| topic | recurrent respiratory tract infections probiotics children prevention health |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1508613/full |
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