A Near-Fatal Infection with Oseltamivir-Resistant Seasonal Influenza A in a Previously Healthy Child: Case Report

A case of near-fatal oseltamivir-resistant seasonal influenza A infection in a previously healthy four-year-old boy is reported. This case highlights three important points for physicians: oseltamivir-resistant influenza A (H1N1) has recently emerged in North America; contrary to previously held bel...

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Main Authors: Jesse Papenburg, Christos Karatzios, Yan Li, Nathalie Bastien, Makeda Semret, Dorothy Moore
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:Canadian Journal of Infectious Diseases and Medical Microbiology
Online Access:http://dx.doi.org/10.1155/2009/424093
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author Jesse Papenburg
Christos Karatzios
Yan Li
Nathalie Bastien
Makeda Semret
Dorothy Moore
author_facet Jesse Papenburg
Christos Karatzios
Yan Li
Nathalie Bastien
Makeda Semret
Dorothy Moore
author_sort Jesse Papenburg
collection DOAJ
description A case of near-fatal oseltamivir-resistant seasonal influenza A infection in a previously healthy four-year-old boy is reported. This case highlights three important points for physicians: oseltamivir-resistant influenza A (H1N1) has recently emerged in North America; contrary to previously held beliefs, such strains are capable of causing severe disease in healthy children; and given this change in epidemiology, clinicians caring for children with severe seasonal influenza A infection should consider empiric dual therapy with oseltamivir and amantadine.
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institution Kabale University
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series Canadian Journal of Infectious Diseases and Medical Microbiology
spelling doaj-art-1f98e1315bb5469495e16cbb758389192025-02-03T05:52:50ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322009-01-01204e173e17610.1155/2009/424093A Near-Fatal Infection with Oseltamivir-Resistant Seasonal Influenza A in a Previously Healthy Child: Case ReportJesse Papenburg0Christos Karatzios1Yan Li2Nathalie Bastien3Makeda Semret4Dorothy Moore5Infectious Diseases Division, Department of Pediatrics, Montreal Children’s Hospital, CanadaInfectious Diseases Division, Department of Pediatrics, Montreal Children’s Hospital, CanadaNational Microbiology Laboratory, Canadian Science Center for Human and Animal Health, Winnipeg, Manitoba, CanadaNational Microbiology Laboratory, Canadian Science Center for Human and Animal Health, Winnipeg, Manitoba, CanadaDepartment of Microbiology, McGill University Health Centre, Montreal, Québec, CanadaInfectious Diseases Division, Department of Pediatrics, Montreal Children’s Hospital, CanadaA case of near-fatal oseltamivir-resistant seasonal influenza A infection in a previously healthy four-year-old boy is reported. This case highlights three important points for physicians: oseltamivir-resistant influenza A (H1N1) has recently emerged in North America; contrary to previously held beliefs, such strains are capable of causing severe disease in healthy children; and given this change in epidemiology, clinicians caring for children with severe seasonal influenza A infection should consider empiric dual therapy with oseltamivir and amantadine.http://dx.doi.org/10.1155/2009/424093
spellingShingle Jesse Papenburg
Christos Karatzios
Yan Li
Nathalie Bastien
Makeda Semret
Dorothy Moore
A Near-Fatal Infection with Oseltamivir-Resistant Seasonal Influenza A in a Previously Healthy Child: Case Report
Canadian Journal of Infectious Diseases and Medical Microbiology
title A Near-Fatal Infection with Oseltamivir-Resistant Seasonal Influenza A in a Previously Healthy Child: Case Report
title_full A Near-Fatal Infection with Oseltamivir-Resistant Seasonal Influenza A in a Previously Healthy Child: Case Report
title_fullStr A Near-Fatal Infection with Oseltamivir-Resistant Seasonal Influenza A in a Previously Healthy Child: Case Report
title_full_unstemmed A Near-Fatal Infection with Oseltamivir-Resistant Seasonal Influenza A in a Previously Healthy Child: Case Report
title_short A Near-Fatal Infection with Oseltamivir-Resistant Seasonal Influenza A in a Previously Healthy Child: Case Report
title_sort near fatal infection with oseltamivir resistant seasonal influenza a in a previously healthy child case report
url http://dx.doi.org/10.1155/2009/424093
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