Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis
Amyloidosis is characterized by extracellular deposition of protein fibrils of chemically heterogeneous composition. Early recognition and identification of amyloid deposits allows an early start of therapy, which may entail a better prognosis. Congo red staining according to Romhányi (1971) is a hi...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.35 |
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| author | M. Bély |
| author_facet | M. Bély |
| author_sort | M. Bély |
| collection | DOAJ |
| description | Amyloidosis is characterized by extracellular deposition of protein fibrils of chemically heterogeneous composition. Early recognition and identification of amyloid deposits allows an early start of therapy, which may entail a better prognosis. Congo red staining according to Romhányi (1971) is a highly specific and sensitive method for early microscopic recognition of amyloidosis. The main and most important types of amyloidosis may be distinguished by classic histochemical methods of performate pretreatment according to Romhányi (1979), or by KMnO4 oxidation according to Wright (1977) followed by Congo red staining and viewed under polarized light. Differences in the speed of breakdown (disintegration) of amyloid deposits according to Bély and Apáthy allow a more precise distinction of various types of amyloid. |
| format | Article |
| id | doaj-art-1f93dc30d6fe4cc6a43c8615bd8d89b0 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1f93dc30d6fe4cc6a43c8615bd8d89b02025-02-03T01:26:53ZengWileyThe Scientific World Journal1537-744X2006-01-01615416810.1100/tsw.2006.35Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and AmyloidosisM. Bély0Department of Pathology, Policlinic of the Hospitaller Brothers of St. John of God at Budapest, Frankel Leo Street 17-19, Budapest, HungaryAmyloidosis is characterized by extracellular deposition of protein fibrils of chemically heterogeneous composition. Early recognition and identification of amyloid deposits allows an early start of therapy, which may entail a better prognosis. Congo red staining according to Romhányi (1971) is a highly specific and sensitive method for early microscopic recognition of amyloidosis. The main and most important types of amyloidosis may be distinguished by classic histochemical methods of performate pretreatment according to Romhányi (1979), or by KMnO4 oxidation according to Wright (1977) followed by Congo red staining and viewed under polarized light. Differences in the speed of breakdown (disintegration) of amyloid deposits according to Bély and Apáthy allow a more precise distinction of various types of amyloid.http://dx.doi.org/10.1100/tsw.2006.35 |
| spellingShingle | M. Bély Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis The Scientific World Journal |
| title | Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis |
| title_full | Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis |
| title_fullStr | Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis |
| title_full_unstemmed | Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis |
| title_short | Histochemical Differential Diagnosis and Polarization Optical Analysis of Amyloid and Amyloidosis |
| title_sort | histochemical differential diagnosis and polarization optical analysis of amyloid and amyloidosis |
| url | http://dx.doi.org/10.1100/tsw.2006.35 |
| work_keys_str_mv | AT mbely histochemicaldifferentialdiagnosisandpolarizationopticalanalysisofamyloidandamyloidosis |