Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
Epigenetic mechanisms have been suggested to play a role in the genetic regulation of pathways related to inflammation. Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood....
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/6273680 |
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| author | Valentina Gonzalez-Jaramillo Eliana Portilla-Fernandez Marija Glisic Trudy Voortman Mohsen Ghanbari Wichor Bramer Rajiv Chowdhury Tamar Nijsten Abbas Dehghan Oscar H. Franco Jana Nano |
| author_facet | Valentina Gonzalez-Jaramillo Eliana Portilla-Fernandez Marija Glisic Trudy Voortman Mohsen Ghanbari Wichor Bramer Rajiv Chowdhury Tamar Nijsten Abbas Dehghan Oscar H. Franco Jana Nano |
| author_sort | Valentina Gonzalez-Jaramillo |
| collection | DOAJ |
| description | Epigenetic mechanisms have been suggested to play a role in the genetic regulation of pathways related to inflammation. Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood. Five bibliographic databases were screened until 21 November of 2017. We included studies conducted on humans that examined the association between epigenetic marks (DNA methylation and/or histone modifications) and a comprehensive list of inflammatory markers. Of the 3,759 identified references, 24 articles were included, involving, 17,399 individuals. There was suggestive evidence for global hypomethylation but better-quality studies in the future have to confirm this. Epigenome-wide association studies (EWAS) (n=7) reported most of the identified differentially methylated genes to be hypomethylated in inflammatory processes. Candidate genes studies reported 18 differentially methylated genes related to several circulatory inflammation markers. There was no overlap in the methylated sites investigated in candidate gene studies and EWAS, except for TMEM49, which was found to be hypomethylated with higher inflammatory markers in both types of studies. The relation between histone modifications and inflammatory markers was assessed by one study only. This review supports an association between epigenetic marks and inflammation, suggesting hypomethylation of the genome. Important gaps in the quality of studies were reported such as inadequate sample size, lack of adjustment for relevant confounders, and failure to replicate the findings. While most of the studies have been focused on C-reactive protein, further efforts should investigate other inflammatory markers. |
| format | Article |
| id | doaj-art-1f6b821e5ddc442ebcb96664e88bcb03 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-1f6b821e5ddc442ebcb96664e88bcb032025-02-03T06:13:13ZengWileyInternational Journal of Inflammation2090-80402042-00992019-01-01201910.1155/2019/62736806273680Epigenetics and Inflammatory Markers: A Systematic Review of the Current EvidenceValentina Gonzalez-Jaramillo0Eliana Portilla-Fernandez1Marija Glisic2Trudy Voortman3Mohsen Ghanbari4Wichor Bramer5Rajiv Chowdhury6Tamar Nijsten7Abbas Dehghan8Oscar H. Franco9Jana Nano10Department of Epidemiology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsDepartment of Epidemiology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsDepartment of Epidemiology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsDepartment of Epidemiology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsDepartment of Epidemiology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsMedical Library, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsDepartment of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, CB1 8RN, Cambridge, UKDepartment of Dermatology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsDepartment of Epidemiology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsDepartment of Epidemiology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsDepartment of Epidemiology, Erasmus MC, Erasmus University Medical Center, 3015 CN, Rotterdam, NetherlandsEpigenetic mechanisms have been suggested to play a role in the genetic regulation of pathways related to inflammation. Therefore, we aimed to systematically review studies investigating the association between DNA methylation and histone modifications with circulatory inflammation markers in blood. Five bibliographic databases were screened until 21 November of 2017. We included studies conducted on humans that examined the association between epigenetic marks (DNA methylation and/or histone modifications) and a comprehensive list of inflammatory markers. Of the 3,759 identified references, 24 articles were included, involving, 17,399 individuals. There was suggestive evidence for global hypomethylation but better-quality studies in the future have to confirm this. Epigenome-wide association studies (EWAS) (n=7) reported most of the identified differentially methylated genes to be hypomethylated in inflammatory processes. Candidate genes studies reported 18 differentially methylated genes related to several circulatory inflammation markers. There was no overlap in the methylated sites investigated in candidate gene studies and EWAS, except for TMEM49, which was found to be hypomethylated with higher inflammatory markers in both types of studies. The relation between histone modifications and inflammatory markers was assessed by one study only. This review supports an association between epigenetic marks and inflammation, suggesting hypomethylation of the genome. Important gaps in the quality of studies were reported such as inadequate sample size, lack of adjustment for relevant confounders, and failure to replicate the findings. While most of the studies have been focused on C-reactive protein, further efforts should investigate other inflammatory markers.http://dx.doi.org/10.1155/2019/6273680 |
| spellingShingle | Valentina Gonzalez-Jaramillo Eliana Portilla-Fernandez Marija Glisic Trudy Voortman Mohsen Ghanbari Wichor Bramer Rajiv Chowdhury Tamar Nijsten Abbas Dehghan Oscar H. Franco Jana Nano Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence International Journal of Inflammation |
| title | Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence |
| title_full | Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence |
| title_fullStr | Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence |
| title_full_unstemmed | Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence |
| title_short | Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence |
| title_sort | epigenetics and inflammatory markers a systematic review of the current evidence |
| url | http://dx.doi.org/10.1155/2019/6273680 |
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