Pradofloxacin Minimum Inhibitory Concentration Profiling of <i>Streptococcus suis</i> Isolates: Insights into Antimicrobial Susceptibility in Swine
This study evaluated the minimum inhibitory concentration (MIC) of pradofloxacin against various swine respiratory pathogens, including <i>Bordetella bronchiseptica</i>, <i>Glaesserella parasuis</i>, <i>Mycoplasma hyopneumoniae</i>, <i>Pasteurella multocida&...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/14/1/88 |
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| Summary: | This study evaluated the minimum inhibitory concentration (MIC) of pradofloxacin against various swine respiratory pathogens, including <i>Bordetella bronchiseptica</i>, <i>Glaesserella parasuis</i>, <i>Mycoplasma hyopneumoniae</i>, <i>Pasteurella multocida</i>, and <i>Streptococcus suis</i> (<i>S. suis</i>), associated with disease in swine. This research was conducted in two phases: the initial phase examined isolates from the lungs that could be either commensal or pathogenic, while the second phase focused on systemic <i>S. suis</i> strains that spread from the respiratory tract to the brain. The pradofloxacin MIC values of the second phase were within the MIC range of the initial phase, with MIC<sub>50</sub> and MIC<sub>90</sub> values highlighting its potential as an effective antimicrobial agent. Quality control data validated the reliability of our MIC findings, with all pradofloxacin MIC values for control organisms within approved ranges. These findings suggest that pradofloxacin has broad-spectrum activity against Gram-positive and Gram-negative bacteria and may serve as a reliable therapeutic option for managing <i>S. suis</i> and other swine respiratory infections. This study highlights pradofloxacin as an alternative antimicrobial therapy for swine respiratory diseases, offering a potential solution amidst rising concerns over antibiotic resistance. |
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| ISSN: | 2076-0817 |