RIG-I and cGAS mediate antimicrobial and inflammatory responses of primary osteoblasts and osteoclasts to Staphylococcus aureus

RIG-I and cGAS mediate antimicrobial and inflammatory responses of primary osteoblasts and osteoclasts to Staphylococcus aureus

ABSTRACT Staphylococcus aureus is the primary causative agent of osteomyelitis, and it is now apparent that osteoblasts and osteoclasts play a significant role in the pathogenesis of such infections. Their responses can either be protective or exacerbate inflammatory bone loss and are mediated by th...

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Bibliographic Details
Main Authors: Erin L. Mills, Samantha R. Suptela, Mary-Kate Key, Ian Marriott, M. Brittany Johnson
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
osteoblasts
osteoclasts
Staphylococcus aureus
RIG-I
cGAS
cytokines
Online Access:https://journals.asm.org/doi/10.1128/mbio.03971-24
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