The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas
Aim: Recent studies have shown that sirtuin signaling pathway activation could be a potential therapeutic target for future therapies and biomarkers for predicting prognosis in cancer. We aimed to investigate the association between Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) immunohistochemical (IHC) p...
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| Format: | Article |
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Galenos Yayinevi
2024-11-01
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| Series: | Haseki Tıp Bülteni |
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| Online Access: | https://www.hasekidergisi.com/articles/the-relationship-of-sirtuin-1-and-sirtuin-2-expression-with-clinicopathological-parameters-in-non-small-cell-lung-carcinomas/doi/haseki.galenos.2024.9664 |
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| author | Fatma Cakmak Kazanci Nagehan Barisik Ozdemir Sibel Sensu Cem Cahit Barisik |
| author_facet | Fatma Cakmak Kazanci Nagehan Barisik Ozdemir Sibel Sensu Cem Cahit Barisik |
| author_sort | Fatma Cakmak Kazanci |
| collection | DOAJ |
| description | Aim: Recent studies have shown that sirtuin signaling pathway activation could be a potential therapeutic target for future therapies and biomarkers for predicting prognosis in cancer. We aimed to investigate the association between Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) immunohistochemical (IHC) protein expression in tumors and clinicopathological parameters and survival profiles in non-small cell lung cancer (NSCLC) patients.
Methods: This retrospective observational study reviewed lung resections (lobectomy, segmentectomy, wedge resection, and pneumonectomy) of 186 patients diagnosed with NSCLC (adenocarcinoma, squamous cell carcinoma, and adenosquamous carcinoma). SIRT1 and SIRT2 expression was classified as high and low expression based on the extent and intensity of IHC staining.
Results: When there was advanced disease, a large tumor, and metastasis to lymph nodes, low levels of SIRT1 and SIRT2 expression were found. A positive correlation exists between high SIRT2 expression and longer overall survival. If SIRT1 and SIRT2 were both overexpressed (+/+), longer survival times were observed than in the group in which either of them was low (+/-, -/+, -/-) (p=0.01).
Conclusion: Our research suggests that SIRT1 and SIRT2 may suppress tumor growth in NSCLC and serve as positive prognostic indicators. |
| format | Article |
| id | doaj-art-1f3bfa07a1c64d22bfb9dcba030f15a4 |
| institution | Kabale University |
| issn | 1302-0072 2147-2688 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj-art-1f3bfa07a1c64d22bfb9dcba030f15a42025-01-28T07:16:05ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882024-11-0162527227910.4274/haseki.galenos.2024.9664The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung CarcinomasFatma Cakmak Kazanci0https://orcid.org/0000-0001-5064-0952Nagehan Barisik Ozdemir1https://orcid.org/0000-0002-6606-1848Sibel Sensu2https://orcid.org/0000-0002-4607-780XCem Cahit Barisik3https://orcid.org/0000-0003-3540-6492University of Health Sciences Turkey, Kartal Dr. Lutfi Kirdar City Hospital, Clinic of Pathology, Istanbul, TurkeyUniversity of Health Sciences Turkey, Kartal Dr. Lutfi Kirdar City Hospital, Clinic of Pathology, Istanbul, TurkeyIstinye University Faculty of Medicine, Department of Pathology, Istanbul, TurkeyMedipol University Faculty of Medicine, Department of Radiology, Istanbul, TurkeyAim: Recent studies have shown that sirtuin signaling pathway activation could be a potential therapeutic target for future therapies and biomarkers for predicting prognosis in cancer. We aimed to investigate the association between Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) immunohistochemical (IHC) protein expression in tumors and clinicopathological parameters and survival profiles in non-small cell lung cancer (NSCLC) patients. Methods: This retrospective observational study reviewed lung resections (lobectomy, segmentectomy, wedge resection, and pneumonectomy) of 186 patients diagnosed with NSCLC (adenocarcinoma, squamous cell carcinoma, and adenosquamous carcinoma). SIRT1 and SIRT2 expression was classified as high and low expression based on the extent and intensity of IHC staining. Results: When there was advanced disease, a large tumor, and metastasis to lymph nodes, low levels of SIRT1 and SIRT2 expression were found. A positive correlation exists between high SIRT2 expression and longer overall survival. If SIRT1 and SIRT2 were both overexpressed (+/+), longer survival times were observed than in the group in which either of them was low (+/-, -/+, -/-) (p=0.01). Conclusion: Our research suggests that SIRT1 and SIRT2 may suppress tumor growth in NSCLC and serve as positive prognostic indicators.https://www.hasekidergisi.com/articles/the-relationship-of-sirtuin-1-and-sirtuin-2-expression-with-clinicopathological-parameters-in-non-small-cell-lung-carcinomas/doi/haseki.galenos.2024.9664lungnon-small-cell carcinomasirtuin 1sirtuin 2prognosisimmunohistochemistry |
| spellingShingle | Fatma Cakmak Kazanci Nagehan Barisik Ozdemir Sibel Sensu Cem Cahit Barisik The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas Haseki Tıp Bülteni lung non-small-cell carcinoma sirtuin 1 sirtuin 2 prognosis immunohistochemistry |
| title | The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas |
| title_full | The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas |
| title_fullStr | The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas |
| title_full_unstemmed | The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas |
| title_short | The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas |
| title_sort | relationship of sirtuin 1 and sirtuin 2 expression with clinicopathological parameters in non small cell lung carcinomas |
| topic | lung non-small-cell carcinoma sirtuin 1 sirtuin 2 prognosis immunohistochemistry |
| url | https://www.hasekidergisi.com/articles/the-relationship-of-sirtuin-1-and-sirtuin-2-expression-with-clinicopathological-parameters-in-non-small-cell-lung-carcinomas/doi/haseki.galenos.2024.9664 |
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