Compressibility of tableting materials and properties of tablets with glyceryl behenate
The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2015-03-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2015-0006 |
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| _version_ | 1832572462321106944 |
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| author | Mužíková Jitka Muchová Sandra Komersová Alena Lochař Václav |
| author_facet | Mužíková Jitka Muchová Sandra Komersová Alena Lochař Václav |
| author_sort | Mužíková Jitka |
| collection | DOAJ |
| description | The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also examined. In the case of microcrystalline cellulose, a higher concentration of glyceryl dibehenate increased the strength of tablets, while this did not occur in the case of spray-dried lactose. Increasing concentration of glyceryl dibehenate prolonged the release of salicylic acid; however, no statistically significant difference was found compared to the type of the dry binder used |
| format | Article |
| id | doaj-art-1f396d7e225d432fb981f773c9e8f298 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2015-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-1f396d7e225d432fb981f773c9e8f2982025-02-02T09:47:34ZengSciendoActa Pharmaceutica1846-95582015-03-01651919810.1515/acph-2015-0006acph-2015-0006Compressibility of tableting materials and properties of tablets with glyceryl behenateMužíková Jitka0Muchová Sandra1Komersová Alena2Lochař Václav3Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech RepublicDepartment of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech RepublicDepartment of Physical Chemistry University of Pardubice, Faculty of Chemical Technology, Pardubice Czech RepublicDepartment of Physical Chemistry University of Pardubice, Faculty of Chemical Technology, Pardubice Czech RepublicThe paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also examined. In the case of microcrystalline cellulose, a higher concentration of glyceryl dibehenate increased the strength of tablets, while this did not occur in the case of spray-dried lactose. Increasing concentration of glyceryl dibehenate prolonged the release of salicylic acid; however, no statistically significant difference was found compared to the type of the dry binder usedhttps://doi.org/10.1515/acph-2015-0006lipophilic matrix tabletglyceryl dibehenatesalicylic acidenergy profile of compressiontensile strength of tabletsdissolution profile |
| spellingShingle | Mužíková Jitka Muchová Sandra Komersová Alena Lochař Václav Compressibility of tableting materials and properties of tablets with glyceryl behenate Acta Pharmaceutica lipophilic matrix tablet glyceryl dibehenate salicylic acid energy profile of compression tensile strength of tablets dissolution profile |
| title | Compressibility of tableting materials and properties of tablets with glyceryl behenate |
| title_full | Compressibility of tableting materials and properties of tablets with glyceryl behenate |
| title_fullStr | Compressibility of tableting materials and properties of tablets with glyceryl behenate |
| title_full_unstemmed | Compressibility of tableting materials and properties of tablets with glyceryl behenate |
| title_short | Compressibility of tableting materials and properties of tablets with glyceryl behenate |
| title_sort | compressibility of tableting materials and properties of tablets with glyceryl behenate |
| topic | lipophilic matrix tablet glyceryl dibehenate salicylic acid energy profile of compression tensile strength of tablets dissolution profile |
| url | https://doi.org/10.1515/acph-2015-0006 |
| work_keys_str_mv | AT muzikovajitka compressibilityoftabletingmaterialsandpropertiesoftabletswithglycerylbehenate AT muchovasandra compressibilityoftabletingmaterialsandpropertiesoftabletswithglycerylbehenate AT komersovaalena compressibilityoftabletingmaterialsandpropertiesoftabletswithglycerylbehenate AT locharvaclav compressibilityoftabletingmaterialsandpropertiesoftabletswithglycerylbehenate |