The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation
Background. There are challenges in the clinical diagnosis of drug-induced injury and in obtaining information on the reactivation of human herpes viruses (HHV) during idiosyncratic adverse drug reactions. Objectives. (i) To develop a unified list of drugs incriminated in drug-induced hepatotoxicity...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/723062 |
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| author | Joshua C. Pritchett Radu M. Nanau Manuela G. Neuman |
| author_facet | Joshua C. Pritchett Radu M. Nanau Manuela G. Neuman |
| author_sort | Joshua C. Pritchett |
| collection | DOAJ |
| description | Background. There are challenges in the clinical diagnosis of drug-induced injury and in obtaining information on the reactivation of human herpes viruses (HHV) during idiosyncratic adverse drug reactions. Objectives. (i) To develop a unified list of drugs incriminated in drug-induced hepatotoxicity and severe cutaneous reactions, in which drug hypersensitivity leads to HHV-6 reactivation and further complication of therapy and recovery and (ii) to supplement the already available data on reporting frequencies of liver- or skin-induced cases with knowledge of individual case reports, including HHV-6 reactivation and briefly introducing chromosomally integrated HHV-6.
Data Sources and Extraction. Drugs identified as causes of (i) idiosyncratic reactions, (ii) drug-induced hypersensitivity, drug-induced hepatotoxicity, acute liver failure, and Stevens-Johnson syndrome, and (iii) human herpes virus reactivation in PubMed since 1997 have been collected and discussed. Results. Data presented in this paper show that HHV-6 reactivation is associated with more severe organ involvement and a prolonged course of disease. Conclusion. This analysis of HHV-6 reactivation associated with drug-induced severe cutaneous reactions and hepatotoxicity will aid in causality assessment and clinical diagnosis of possible life-threatening events and will provide a basis for further patient characterization and therapy. |
| format | Article |
| id | doaj-art-1f2998dc5cfa434da0e67c2d7a41e37d |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-1f2998dc5cfa434da0e67c2d7a41e37d2025-02-03T01:28:57ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/723062723062The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 ReactivationJoshua C. Pritchett0Radu M. Nanau1Manuela G. Neuman2HHV-6 Foundation, Santa Barbara, CA 93108, USADepartment of Pharmacology and Toxicology, University of Toronto and In Vitro Drug Safety and Biotechnology, Toronto, ON, M5G 1L7, CanadaDepartment of Pharmacology and Toxicology, University of Toronto and In Vitro Drug Safety and Biotechnology, Toronto, ON, M5G 1L7, CanadaBackground. There are challenges in the clinical diagnosis of drug-induced injury and in obtaining information on the reactivation of human herpes viruses (HHV) during idiosyncratic adverse drug reactions. Objectives. (i) To develop a unified list of drugs incriminated in drug-induced hepatotoxicity and severe cutaneous reactions, in which drug hypersensitivity leads to HHV-6 reactivation and further complication of therapy and recovery and (ii) to supplement the already available data on reporting frequencies of liver- or skin-induced cases with knowledge of individual case reports, including HHV-6 reactivation and briefly introducing chromosomally integrated HHV-6. Data Sources and Extraction. Drugs identified as causes of (i) idiosyncratic reactions, (ii) drug-induced hypersensitivity, drug-induced hepatotoxicity, acute liver failure, and Stevens-Johnson syndrome, and (iii) human herpes virus reactivation in PubMed since 1997 have been collected and discussed. Results. Data presented in this paper show that HHV-6 reactivation is associated with more severe organ involvement and a prolonged course of disease. Conclusion. This analysis of HHV-6 reactivation associated with drug-induced severe cutaneous reactions and hepatotoxicity will aid in causality assessment and clinical diagnosis of possible life-threatening events and will provide a basis for further patient characterization and therapy.http://dx.doi.org/10.1155/2012/723062 |
| spellingShingle | Joshua C. Pritchett Radu M. Nanau Manuela G. Neuman The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation International Journal of Hepatology |
| title | The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation |
| title_full | The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation |
| title_fullStr | The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation |
| title_full_unstemmed | The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation |
| title_short | The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation |
| title_sort | link between hypersensitivity syndrome reaction development and human herpes virus 6 reactivation |
| url | http://dx.doi.org/10.1155/2012/723062 |
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