Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection
A 19-month-old boy with chronic granulomatous disease (CGD) received umbilical cord blood transplantation (UCBT) from an unrelated donor after experiencing a life-threatening disseminated Bacillus Calmette–Guérin infection. After busulfan and cyclophosphamide conditioning, we performed a 5/6-matched...
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| Language: | English |
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Elsevier
2015-10-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957213000703 |
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| author | Chao-Jen Lin Shih-Chung Wang Cheng-Lung Ku Jun-kai Kao Ming Chen Chin-San Liu |
| author_facet | Chao-Jen Lin Shih-Chung Wang Cheng-Lung Ku Jun-kai Kao Ming Chen Chin-San Liu |
| author_sort | Chao-Jen Lin |
| collection | DOAJ |
| description | A 19-month-old boy with chronic granulomatous disease (CGD) received umbilical cord blood transplantation (UCBT) from an unrelated donor after experiencing a life-threatening disseminated Bacillus Calmette–Guérin infection. After busulfan and cyclophosphamide conditioning, we performed a 5/6-matched UCBT. Engraftment and mixed chimerism was 100% in peripheral blood, and 100% of his neutrophils had normal oxidative burst activity on day 17. The patient is now 3 years old, free from infection, and growing well. To our knowledge, this is the second case of CGD treated with UCBT in Taiwan. His successful outcome illustrates that UCBT in a patient with CGD should be considered early if a human leukocyte antigen-matched donor is not available or the patient has just recovered from a severe infection. |
| format | Article |
| id | doaj-art-1f227b8ef26c4cbbb4ae7bfd615af17a |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2015-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-1f227b8ef26c4cbbb4ae7bfd615af17a2025-08-20T01:59:01ZengElsevierPediatrics and Neonatology1875-95722015-10-0156534635010.1016/j.pedneo.2013.04.001Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced InfectionChao-Jen Lin0Shih-Chung Wang1Cheng-Lung Ku2Jun-kai Kao3Ming Chen4Chin-San Liu5Department of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan, ROCDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan, ROCGraduate Institute of Clinical Medical Science, Chang-Gung University, Tao-Yuan, Taiwan, ROCDepartment of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan, ROCCenter for Medical Genetics, Changhua Christian Children's Hospital, Changhua, Taiwan, ROCVascular and Genomic Center, Changhua Christian Children's Hospital, Changhua, Taiwan, ROCA 19-month-old boy with chronic granulomatous disease (CGD) received umbilical cord blood transplantation (UCBT) from an unrelated donor after experiencing a life-threatening disseminated Bacillus Calmette–Guérin infection. After busulfan and cyclophosphamide conditioning, we performed a 5/6-matched UCBT. Engraftment and mixed chimerism was 100% in peripheral blood, and 100% of his neutrophils had normal oxidative burst activity on day 17. The patient is now 3 years old, free from infection, and growing well. To our knowledge, this is the second case of CGD treated with UCBT in Taiwan. His successful outcome illustrates that UCBT in a patient with CGD should be considered early if a human leukocyte antigen-matched donor is not available or the patient has just recovered from a severe infection.http://www.sciencedirect.com/science/article/pii/S1875957213000703chronic granulomatous disease (CGD)disseminated Bacillus Calmette–Guérin (BCG) infectionumbilical cord blood transplantation (UCBT) |
| spellingShingle | Chao-Jen Lin Shih-Chung Wang Cheng-Lung Ku Jun-kai Kao Ming Chen Chin-San Liu Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection Pediatrics and Neonatology chronic granulomatous disease (CGD) disseminated Bacillus Calmette–Guérin (BCG) infection umbilical cord blood transplantation (UCBT) |
| title | Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection |
| title_full | Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection |
| title_fullStr | Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection |
| title_full_unstemmed | Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection |
| title_short | Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection |
| title_sort | successful unrelated cord blood stem cell transplantation in an x linked chronic granulomatous disease patient with disseminated bcg induced infection |
| topic | chronic granulomatous disease (CGD) disseminated Bacillus Calmette–Guérin (BCG) infection umbilical cord blood transplantation (UCBT) |
| url | http://www.sciencedirect.com/science/article/pii/S1875957213000703 |
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