Beliefs about medicines’ association with endocrine therapy adherence in early breast cancer survivors in Croatia
This observational, cross-sectional study conducted at the University Hospital Centre Zagreb (UHC Zagreb) aimed to explore patients’ beliefs about adjuvant endocrine therapy (AET) as well as their association with non-adherence and sociodemographic and clinical factors. Out of 420 early breast cance...
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| Format: | Article |
| Language: | English |
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Sciendo
2023-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2023-0043 |
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| author | Okroša Ana Dugonjić Silovski Tajana Plavetić Natalija Dedić Silovski Hrvoje Kovačić Ana Mucalo Iva |
| author_facet | Okroša Ana Dugonjić Silovski Tajana Plavetić Natalija Dedić Silovski Hrvoje Kovačić Ana Mucalo Iva |
| author_sort | Okroša Ana Dugonjić |
| collection | DOAJ |
| description | This observational, cross-sectional study conducted at the University Hospital Centre Zagreb (UHC Zagreb) aimed to explore patients’ beliefs about adjuvant endocrine therapy (AET) as well as their association with non-adherence and sociodemographic and clinical factors. Out of 420 early breast cancer (BC) patients included in the study, 79.5 % perceived AET necessary and important for their health, as measured by the Belief About Medicines Questionnaire (BMQ), with the mean necessity score (20.4 ± 3.68) significantly higher than the mean concerns score (13 ± 4.81) (p < 0.001). Based on the Medication Adherence Report Scale (MARS-5), 44.4 % (n = 182) of the participants were non-adherers, out of which 63.2 % (n = 115) were unintentional and 36.8 % (n = 67) intentional non-adherers. Significantly higher concern beliefs were found among patients that were younger (p < 0.001), employed (p < 0.001), intentionally non-adherent to AET (p = 0.006), had a lower body-mass index (p = 0.005) and a higher level of education (p < 0.001), were premenopausal at the time of diagnosis (p < 0.001), taking tamoxifen treatment (p = 0.05) and receiving ovarian suppression (p < 0.001). Younger patients should be recognized as being at risk of non-adherence as they hold greater concern beliefs about medicines. |
| format | Article |
| id | doaj-art-1f225a94dd7249648b7d2b32795544b8 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-1f225a94dd7249648b7d2b32795544b82025-02-03T09:59:34ZengSciendoActa Pharmaceutica1846-95582023-12-0173467368910.2478/acph-2023-0043Beliefs about medicines’ association with endocrine therapy adherence in early breast cancer survivors in CroatiaOkroša Ana Dugonjić0Silovski Tajana1Plavetić Natalija Dedić2Silovski Hrvoje3Kovačić Ana4Mucalo Iva51Agency for Medicinal Products and Medical Devices of Croatia, ZagrebCroatia2Department of Oncology, University Hospital Centre Zagreb, Zagreb, Croatia2Department of Oncology, University Hospital Centre Zagreb, Zagreb, Croatia3University of Zagreb, Medical School Zagreb, Croatia5University of Zagreb Faculty of Food Technology and Biotechnology, ZagrebCroatia6University of Zagreb Faculty of Pharmacy and Biochemistry, ZagrebCroatiaThis observational, cross-sectional study conducted at the University Hospital Centre Zagreb (UHC Zagreb) aimed to explore patients’ beliefs about adjuvant endocrine therapy (AET) as well as their association with non-adherence and sociodemographic and clinical factors. Out of 420 early breast cancer (BC) patients included in the study, 79.5 % perceived AET necessary and important for their health, as measured by the Belief About Medicines Questionnaire (BMQ), with the mean necessity score (20.4 ± 3.68) significantly higher than the mean concerns score (13 ± 4.81) (p < 0.001). Based on the Medication Adherence Report Scale (MARS-5), 44.4 % (n = 182) of the participants were non-adherers, out of which 63.2 % (n = 115) were unintentional and 36.8 % (n = 67) intentional non-adherers. Significantly higher concern beliefs were found among patients that were younger (p < 0.001), employed (p < 0.001), intentionally non-adherent to AET (p = 0.006), had a lower body-mass index (p = 0.005) and a higher level of education (p < 0.001), were premenopausal at the time of diagnosis (p < 0.001), taking tamoxifen treatment (p = 0.05) and receiving ovarian suppression (p < 0.001). Younger patients should be recognized as being at risk of non-adherence as they hold greater concern beliefs about medicines.https://doi.org/10.2478/acph-2023-0043breast canceradjuvant endocrine therapybeliefs about medicinesmedication adherencesociodemographic factorsclinical factorshormone-positive breast cancer survivors |
| spellingShingle | Okroša Ana Dugonjić Silovski Tajana Plavetić Natalija Dedić Silovski Hrvoje Kovačić Ana Mucalo Iva Beliefs about medicines’ association with endocrine therapy adherence in early breast cancer survivors in Croatia Acta Pharmaceutica breast cancer adjuvant endocrine therapy beliefs about medicines medication adherence sociodemographic factors clinical factors hormone-positive breast cancer survivors |
| title | Beliefs about medicines’ association with endocrine therapy adherence in early breast cancer survivors in Croatia |
| title_full | Beliefs about medicines’ association with endocrine therapy adherence in early breast cancer survivors in Croatia |
| title_fullStr | Beliefs about medicines’ association with endocrine therapy adherence in early breast cancer survivors in Croatia |
| title_full_unstemmed | Beliefs about medicines’ association with endocrine therapy adherence in early breast cancer survivors in Croatia |
| title_short | Beliefs about medicines’ association with endocrine therapy adherence in early breast cancer survivors in Croatia |
| title_sort | beliefs about medicines association with endocrine therapy adherence in early breast cancer survivors in croatia |
| topic | breast cancer adjuvant endocrine therapy beliefs about medicines medication adherence sociodemographic factors clinical factors hormone-positive breast cancer survivors |
| url | https://doi.org/10.2478/acph-2023-0043 |
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