Comparative and clinical impact of targeted next-generation sequencing in pediatric pneumonia diagnosis and treatment

Comparative and clinical impact of targeted next-generation sequencing in pediatric pneumonia diagnosis and treatment

BackgroundCommunity-acquired pneumonia (CAP) remains a significant cause of pediatric morbidity and mortality worldwide. Conventional microbial tests (CMTs) frequently fail to accurately identify pathogens, especially in cases involving co-infections or less common organisms. Targeted next-generatio...

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Bibliographic Details
Main Authors: Hui Shang, Sini Zou, Zhanying Ma, Qianyu Liang, Ye Zhong, Ling Li, Qishan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
Subjects:
pediatric pneumonia
targeted next-generation sequencing (tNGS)
bronchoalveolar lavage fluid (BALF)
pathogen detection
treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1590792/full
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