The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants
Objective: The study aimed to evaluate the association between microbes in the lower respiratory tract (LRT) and the srisk for severe bronchopulmonary dysplasia (sBPD) in premature infants. Methods: We conducted a retrospective, single-center study of preterm infants who were admitted to the neonata...
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Elsevier
2020-06-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957219305601 |
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| author | Xiao-yan Gao Yi-heng Dai Da-zhi Fan Xiao-yun Xie Guang-di Yang Xin Xiao Ping-ming Gao |
| author_facet | Xiao-yan Gao Yi-heng Dai Da-zhi Fan Xiao-yun Xie Guang-di Yang Xin Xiao Ping-ming Gao |
| author_sort | Xiao-yan Gao |
| collection | DOAJ |
| description | Objective: The study aimed to evaluate the association between microbes in the lower respiratory tract (LRT) and the srisk for severe bronchopulmonary dysplasia (sBPD) in premature infants. Methods: We conducted a retrospective, single-center study of preterm infants who were admitted to the neonatal intensive care unit (NICU) of Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, China, between January 2015 and December 2017. The microbes in the LRT were screened by using tracheobronchial aspirate fluid (TAF) culture. Results: One hundred and fifty-five infants were included in the analysis. Among 155 infants, 41 were diagnosed with sBPD, and 114 were diagnosed without sBPD. There were significant differences between infants with and without sBPD in regard to birth weight (BW), gestational age (GA), the duration of endotracheal ventilation and supplemental oxygen. The incidence of retinopathy (ROP) and sepsis was higher in the sBPD infants than in the infants without sBPD. There was a difference in the detection rate of Gram-negative bacteria (GNB) between the two groups. Stenotrophomonas maltophilia and Klebsiella pneumoniae were mainly detected in TAF. Conclusions: The LRT microbes were different between infants with and without sBPD, and GNB is more frequently detected in sBPD infants. |
| format | Article |
| id | doaj-art-1f13dc8fd6f94f6d86fb44596c1215a1 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-1f13dc8fd6f94f6d86fb44596c1215a12025-08-20T02:11:19ZengElsevierPediatrics and Neonatology1875-95722020-06-0161330631010.1016/j.pedneo.2019.12.010The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infantsXiao-yan Gao0Yi-heng Dai1Da-zhi Fan2Xiao-yun Xie3Guang-di Yang4Xin Xiao5Ping-ming Gao6Department of Neonatology, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, No. 11 Renmin West Road, Chancheng District, Foshan, 528000, ChinaDepartment of Neonatology, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, No. 11 Renmin West Road, Chancheng District, Foshan, 528000, ChinaFoshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, No. 11 Renmin West Road, Chancheng District, Foshan, 528000, ChinaDepartment of Neonatology, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, No. 11 Renmin West Road, Chancheng District, Foshan, 528000, ChinaDepartment of Neonatology, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, No. 11 Renmin West Road, Chancheng District, Foshan, 528000, ChinaDepartment of Neonatology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510120, China; Corresponding author. Department of Neonatology, the Sixth Affiliated Hospital of Sun Yat-sen University, No. 26 Yuancun Erheng Road, Tianhe District, Guangzhou, 510655, China.Fax: +86(0)20-3877 7850Foshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, No. 11 Renmin West Road, Chancheng District, Foshan, 528000, China; Corresponding author.Objective: The study aimed to evaluate the association between microbes in the lower respiratory tract (LRT) and the srisk for severe bronchopulmonary dysplasia (sBPD) in premature infants. Methods: We conducted a retrospective, single-center study of preterm infants who were admitted to the neonatal intensive care unit (NICU) of Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, China, between January 2015 and December 2017. The microbes in the LRT were screened by using tracheobronchial aspirate fluid (TAF) culture. Results: One hundred and fifty-five infants were included in the analysis. Among 155 infants, 41 were diagnosed with sBPD, and 114 were diagnosed without sBPD. There were significant differences between infants with and without sBPD in regard to birth weight (BW), gestational age (GA), the duration of endotracheal ventilation and supplemental oxygen. The incidence of retinopathy (ROP) and sepsis was higher in the sBPD infants than in the infants without sBPD. There was a difference in the detection rate of Gram-negative bacteria (GNB) between the two groups. Stenotrophomonas maltophilia and Klebsiella pneumoniae were mainly detected in TAF. Conclusions: The LRT microbes were different between infants with and without sBPD, and GNB is more frequently detected in sBPD infants.http://www.sciencedirect.com/science/article/pii/S1875957219305601Bronchopulmonary dysplasiaGram-negative bacteriaPretermTracheobronchial aspirate fluid |
| spellingShingle | Xiao-yan Gao Yi-heng Dai Da-zhi Fan Xiao-yun Xie Guang-di Yang Xin Xiao Ping-ming Gao The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants Pediatrics and Neonatology Bronchopulmonary dysplasia Gram-negative bacteria Preterm Tracheobronchial aspirate fluid |
| title | The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants |
| title_full | The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants |
| title_fullStr | The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants |
| title_full_unstemmed | The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants |
| title_short | The association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants |
| title_sort | association between the microbes in the tracheobronchial aspirate fluid and bronchopulmonary dysplasia in preterm infants |
| topic | Bronchopulmonary dysplasia Gram-negative bacteria Preterm Tracheobronchial aspirate fluid |
| url | http://www.sciencedirect.com/science/article/pii/S1875957219305601 |
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